Advances of intraflagellar transport protein 20 in current research

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- Advances of intraflagellar transport protein 20 in current research
- Journal of Chongqing Medical University Vol. 42, Issue 11, Pages: 1375-1378(2017)
- 作者机构：
  
  武汉科技大学医学院公共卫生学院劳动卫生与环境卫生学教研室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.001399
  CLC： R3411
- Published：2017，
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Min Jie, Liu Yunhao, Zhou Ting, et al. Advances of intraflagellar transport protein 20 in current research. [J]. Journal of Chongqing Medical University 42(11):1375-1378(2017)
DOI：

Min Jie, Liu Yunhao, Zhou Ting, et al. Advances of intraflagellar transport protein 20 in current research. [J]. Journal of Chongqing Medical University 42(11):1375-1378(2017) DOI： 10.13406/j.cnki.cyxb.001399.

纤毛内转运蛋白20(intraflagellar transport protein 20

IFT20)是细胞纤毛内转运蛋白B类中的一种

定位于高尔基体

在纤毛内蛋白转运、纤毛组装和维持纤毛正常形态等多种生理功能的调节中具有关键性作用。IFT20的异常表达与肿瘤、多囊肾、免疫紊乱等多种疾病的发生有关

可能是一些重大疾病防治的分子靶点。

intraflagellar transport protein 20（IFT20）is one kind of protein of intraflagellar transport B complex

mainly located in golgi body. IFT20 plays a pivotal role in transporting molecular motors

assembling and maintaining cilia. The defection of IFT20 may cause various diseases including cancer

polycystic kidney disease and immune disorder

making it a molecular target for prevention and treatment of major diseases.

纤毛内转运蛋白20纤毛形成纤毛不动综合征双向转运

intraflagellar transport protein 20ciliogenesisprimary ciliary dyskinesiabidirectional transport

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