Safety and efficacy of antipsychotic drug in the treatment of postoperative delirium: a systematic review and Meta-analysis

Liao Yulin; Yue Jirong; Deng Chuanyao; Gao Langli; Xie Dongmei

doi:10.13406/j.cnki.cyxb.001393

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Safety and efficacy of antipsychotic drug in the treatment of postoperative delirium: a systematic review and Meta-analysis

更新时间：2024-01-17

- Safety and efficacy of antipsychotic drug in the treatment of postoperative delirium: a systematic review and Meta-analysis
- Journal of Chongqing Medical University Vol. 42, Issue 10, Pages: 1299-1303(2017)
- 作者机构：
  
  四川大学华西医院老年医学中心
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.001393
  CLC： R749
- Published：2017，
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Liao Yulin, Yue Jirong, Deng Chuanyao, et al. Safety and efficacy of antipsychotic drug in the treatment of postoperative delirium: a systematic review and Meta-analysis. [J]. Journal of Chongqing Medical University 42(10):1299-1303(2017)
DOI：

Liao Yulin, Yue Jirong, Deng Chuanyao, et al. Safety and efficacy of antipsychotic drug in the treatment of postoperative delirium: a systematic review and Meta-analysis. [J]. Journal of Chongqing Medical University 42(10):1299-1303(2017) DOI： 10.13406/j.cnki.cyxb.001393.

摘要

目的:评价抗精神病药预防老年术后谵妄的疗效及安全性。方法:计算机检索Cochrane图书馆临床对照试验数据库（2015年第10期）、Pub Med、Medline、Embase、中国期刊全文数据库（CNKI）、维普数据库、万方数据库

检索时间均从建库至2015年10月。纳入所有抗精神病药预防老年术后谵妄的安慰剂随机对照研究。采用Rev Man 5.3软件进行Meta分析。结果:最终纳入6个随机对照研究

共1 355例患者。Meta分析结果显示:与安慰剂相比

预防性使用抗精神病药能降低老年术后谵妄的发生率

差异具有统计学意义（RR=0.47

95%CI=0.33

.67

P=0.030）;但在缩短住院时间（MD=-0.02

95%CI=-0.63

.58

P=0.450）及减少死亡率上

两者无统计学差异。结论:现有证据表明

预防性使用抗精神病药能降低老年术后谵妄发生率

但不能缩短谵妄持续时间、住院时间及降低死亡率。受纳入研究数量和质量所限

上述结论可能存在偏倚

需开展更多高质量研究予以验证。

Abstract

Objective:To assess the efficacy and safety of antipsychotic drug for preventing postoperative delirium. Methods:The Cochrane Library（Issue 8

2015）

Medline

Embase

Some related journals the related references were also searched and tracked.Results:Six studies（1355 patients）met the inclusion criteria for analysis. Antipsychotic durg reduced the incidence of postoperative delirium when compared with placebo（RR=0.47

95%CI=0.33 to 0.67

P=0.030）. However

there was no statistically significant difference in length of stay（MD=-0.02

95%CI=-0.63 to 0.58

P=0.450）and the mortality when comparing antipsychotic drug with placebo（P>0.05）. Conclusion:Prophylaxis with antipsychotic medication reduces the risk of post-operative delirium in elderly patients

but not the duration of delirium

length of stay and the mortality.

关键词

谵妄术后抗精神病药预防系统评价Meta分析

Keywords

deliriumpostoperativeantipsychotic drugProphylaxissystemic reviewMeta-analysis

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