Association of the single nucleotide polymorphisms of ADAMTS4 and of ADAMTS5 with coronary heart disease in Chinese Han population

Chen Xiaoyun; Liu Qing; Lei Jiayan; Ding Yanhui; Li Meiling; Zhai Xiuming

doi:10.13406/j.cnki.cyxb.001384

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Association of the single nucleotide polymorphisms of ADAMTS4 and of ADAMTS5 with coronary heart disease in Chinese Han population

更新时间：2024-01-17

- Association of the single nucleotide polymorphisms of ADAMTS4 and of ADAMTS5 with coronary heart disease in Chinese Han population
- Journal of Chongqing Medical University Vol. 42, Issue 9, Pages: 1150-1155(2017)
- 作者机构：
  
  重庆医科大学附属第一医院临床研究中心
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.001384
  CLC： R541.4
- Published：2017，
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Chen Xiaoyun, Liu Qing, Lei Jiayan, et al. Association of the single nucleotide polymorphisms of ADAMTS4 and of ADAMTS5 with coronary heart disease in Chinese Han population. [J]. Journal of Chongqing Medical University 42(9):1150-1155(2017)
DOI：

Chen Xiaoyun, Liu Qing, Lei Jiayan, et al. Association of the single nucleotide polymorphisms of ADAMTS4 and of ADAMTS5 with coronary heart disease in Chinese Han population. [J]. Journal of Chongqing Medical University 42(9):1150-1155(2017) DOI： 10.13406/j.cnki.cyxb.001384.

摘要

目的:探讨ADAMTS4和ADAMTS5基因单核苷酸多态性（single nucleotide polymorphisms

SPN）和冠心病（coronary artery disease

CAD）的相关性。方法:用聚合酶链反应-单链构象多态性（polymerase chain reaction-single-strand conformation polymorphism

PCR-SSCP）方法和聚合酶链反应-限制性片段长度多态性（polymerase chain reaction-restriction fragment length polymorphism

PCR-RFLP）方法检测307例CAD患者和315例对照的rs4233367、rs2830585和rs229072 SNP多态性位点基因型的分布情况。结果:SNPrs2830585在CAD组和对照组中基因型频率为CC（87.0%vs.78.4%）、CT（12.7%vs.20.6%）和TT（0.3%vs.1.0%）

差异有统计学意义（χ

=8.291

P=0.016）

2组间T等位基因频率分别为6.7%和11.3%

差异有统计学意义（χ

=8.004

P=0.005）

经过logistic回归分析后

rs2830585的CT+TT基因型组间差异依然有统计学意义（OR=1.777

95%CI=1.071

.949

P=0.026）。SNPrs4233367和SNPrs229072在CAD组和对照组中基因型和等位基因频率分布差异均无统计学意义（P

0.05）。结论:ADAMTS5基因rs2830585多态性位点与CAD发病相关

C等位基因可能是CAD发生的易感基因。

Abstract

Objective:To investigate the association of single nucleotide polymorphisms（SNP）of ADAMTS4 and ADAMTS5 gene with coronary artery disease（CAD）. Methods:A case-control association study of 307 unrelated CAD patients and 315 normal controlfrom a Chinese Han Population was performed. Genotype and allele were determined bypolymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP）and polymerase chain reaction-single-strand conformation polymorphism（PCR-SSCP）for SNP rs4233367

rs2830585 and rs229072. Results :The genotype frequencies of SNP rs2830585 in CAD group and the control group respectively were CC（87.0% vs. 78.4% ）

CT（12.7% vs. 20.6% ）and TT（0.3% vs. 1.0% ）

with statistically significance between the two groups（χ

=8.291

P=0.016）. The genotype frequencies of T allele were 6.7% and 11.3% respectively

with statistically significance between the two groups（χ

=8.004

P=0.005）. Logistic regression analysis revealed that ADAMTS5 gene rs2830585 had a strong associ ation with CAD（OR=1.777

95% CI=1.071 to 2.949

P=0.026）. Thefrequencies of the genotype and alleles ofrs4233367 and rs229072 had no statistical significance between two groups（P

0.05）. Conclusion:SNP rs2830585 polymorphisms of the ADAMTS5 gene may be associated with CAD. The C allele of the SNP rs2830585 may be a genetic risk factor for CAD.

关键词

冠心病单核苷酸多态性ADAMTS4基因ADAMTS5基因

Keywords

coronary artery diseasesingle nucleotide polymorphismADAMTS4 geneADAMTS5 gene

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