Survival status of patients with esophageal cancer after esophagectomy:a five-year follow-up study

Li Linjun; Zhang Cheng; Zhang Min; Chen Dan; Wu Qingchen; Jiang Yingjiu; Li Qiang

doi:10.13406/j.cnki.cyxb.001381

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Survival status of patients with esophageal cancer after esophagectomy:a five-year follow-up study

更新时间：2024-01-17

- Survival status of patients with esophageal cancer after esophagectomy:a five-year follow-up study
- Journal of Chongqing Medical University Vol. 42, Issue 10, Pages: 1340-1344(2017)
- 作者机构：
  
  重庆医科大学附属第一医院胸心外科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.001381
  CLC： R735.1
- Published：2017，
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Li Linjun, Zhang Cheng, Zhang Min, et al. Survival status of patients with esophageal cancer after esophagectomy:a five-year follow-up study. [J]. Journal of Chongqing Medical University 42(10):1340-1344(2017)
DOI：

Li Linjun, Zhang Cheng, Zhang Min, et al. Survival status of patients with esophageal cancer after esophagectomy:a five-year follow-up study. [J]. Journal of Chongqing Medical University 42(10):1340-1344(2017) DOI： 10.13406/j.cnki.cyxb.001381.

摘要

目的:了解食管癌根治术后生存状态

探索影响预后的相关因素

明确消化道重建方式对预后的影响。方法:以我科2007至2008年期间104例食管癌根治术后患者为研究对象

随机分为管状胃代食管组（narrow gastric tube

NGT

n=52）和全胃代食管组（whole stomach

n=52）;调查研究采用问卷形式

问卷的设计和制定均参照欧洲癌症研究与治疗组织（European Organization for Research and Treatment of Cancer

EORTC）生活质量调查QLQ-C30量表及QLQ-OES18食管癌专用量表

分别以术后3个月、6个月、1年、2年、3年、4年、5年进行随访。纳入年龄、性别、吸烟、饮酒、并发症、TNM分期、淋巴结状态、消化道重建方式8个因素进行分析;采用Life Tables法、Kaplan-Meier法进行生存分析

Log Rank检验、Cox模型回归分析筛选影响预后的相关因素。结果:（1）术后第1、3、5年累积生存率分别为89%、52%、35%

中位生存时间39.60个月;（2）采用后退法（Back:LR）多因素Cox回归分析显示:保留在模型的因素为消化道重建方式（RR=1.798

95%CI=1.084

.983

P=0.023）;淋巴结状态（RR=3.532

95%CI=1.569

.951

P=0.002）;TNM分期（P=0.010）是影响食管癌预后因素。结论:淋巴结状态、TNM分期、消化道重建方式是影响预后的危险因素

管状胃代食管的手术方式可改善患者预后。

Abstract

Objective:To focus on the long-term survival in patients after esophagectomy for cancer and to compare the different methods of reconstruction. Methods :In a prospective randomized single-center study from 2007 to 2008

104 patients undergoing esophageal resection were double-blindly randomly divided into experimental group（52 cases）who received the esophageal reconstruction with the narrow gastric tube（NGT）and control group（52 cases）who received the esophageal reconstruction with the whole stomach（WS）. A questionnaire in reference to the European Organization for Research and Treatment of Cancer（EORTC）QLQ-C30 and the QLQ-OES18 was administered at 3 weeks

6 months

1 year

2 years

3 years

4 years and 5 years after surgery. Clinical data were collected prospectively

and follow-up was performed regularly. Eight factors including age

sex

smoking

drinking

complications

TNM staging

lymph node metastasis and methods of reconstruction were analyzed. The method of Life Tables

Kaplan-Meier

Log Rank and Cox were used. Results:The cumulative survival at 1

5 years after surgery was 89%

52% and 35%

respectively. The median survival was 39.6 moths. Methods of reconstruction（RR=1.798

95%CI=1.084 to 2.983

P=0.023）

lymph node metastasis（RR=3.532

95%CI=1.569 to 7.951

P=0.002）and TNM staging（P=0.010）are factors influencing patients’ survival. Conclusion:Narrow gastric tube reconstruction after oncologic esophagectomy leads to a better survival. TNM staging and lymph node metastasis are independent factors influencing survival.

关键词

食管癌术后生存分析随访研究生存状态

Keywords

esophagectomysurvival analysisfollow-upsurvival status

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