Objective:To analyze perinatal birth defectsincidencein Chongqing from 2005 to 2015

so as to provide scientific basis to formulate preventive care measures to reduce the incidence. Methods:The perinatal birth defects from pregnant 28 weeks to 7 days post-partumfrom 2005 to 2015 were detected and dynamic changes of birth defects were observed. Results:The averageincidence of birth defects was 99.94 per ten thousands perinatal infants with 12 748 cases from 2005 to 2015

and there were significant difference in the incidence of birth defects between the year(χ2=128.059

P=0.000). The average incidence of male birth defects was 110.04 per ten thousands while theincidence of female birth defects was 88.70 per ten thousands. The incidences of birth defects under 20 yearold puerpera group

20 to 35 puerpera group and above 35 year-old puerpera groupwere 108.07 per ten thousands

95.78 per ten thou sandsand 122.03 per ten thousands respectively. The top five birth defects were congenital heart disease(18.63/10 000)

polydactylism(15.04/10 000)

total cleft lip(5.39/10 000)

symphysodactylia(4.27/10 000)and microtia(3.82/10 000). Conclusion:The incidence of perinatal birth defects is not optimistic in Chongqing

especially the diseases such as congenital heart disease. Various measures and comprehensive intervention are required to reduce the incidence of birth defects.