Objective:To study risk factors for atrial fibrillation（AF）in patients with non-alcoholic fatty liver disease（NAFLD）combined with type 2 diabetes. Methods:Totally 208 patients with NAFLD combined with type 2 diabetes were enrolled and the general clinical data and results of conventional electrocardiogram examination

and abdominal ultrasonography were collected. Patients were further divided into AF group and non-AF group

then multiple factors logistic regression model was used to screen the main risk factors. Results:The levels of body mass index

haemoglobin A1 c

total cholesterol（TC）

low density lipoprotein cholesterol

triglyceride

glutamic-oxaloacetic transaminase and glutamyl transpeptidase in AF group were higher than those in non-AF group（P<0.05）. Meanwhile

the proportions of family history of diabetes and fatty liver disease as well as smoking in AF group were higher than those in non-AF group（P<0.01）. In addition

patients in AF group were older compared with non-AF group（P<0.01）. Univariate logistic regression analysis showed that male gender

age

body mass index

family history of diabetes and fatty liver disease

hypertension

levels of haemoglobin A1 c

TC and low density lipoprotein cholesterol were significantly related to higher incidence of AF in patients with both NAFLD and type 2 diabetes（P<0.05）. The age and levels of TC were positive risk factors for AF in the patients with both NAFLD and type 2 diabetes according to the following multivariate logistic regression analysis（OR=2.769

95%CI=1.329 to 5.769

P=0.007;OR=1.435

95%CI=1.027 to 2.014

P=0.005）. Conclusion:The age and TC levels are the risk factor for AF in the patients with NAFLD combined with type 2 diabetes mellitus.