Expression and prognosis of HJURP gene in head and neck cancer based on Oncomine Meta analysis

Zhao Lilin; Chen Yannan; Hu Yu; Zhou Lili

doi:10.13406/j.cnki.cyxb.001329

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Expression and prognosis of HJURP gene in head and neck cancer based on Oncomine Meta analysis

更新时间：2024-01-17

- Expression and prognosis of HJURP gene in head and neck cancer based on Oncomine Meta analysis
- Journal of Chongqing Medical University Vol. 42, Issue 9, Pages: 1095-1098(2017)
- 作者机构：
  
  1. 重庆医科大学附属第一医院口腔科
  2. 重庆市人民医院口腔科
  3. 重庆市人民医院急诊科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.001329
  CLC： R739.91
- Published：2017，
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Zhao Lilin, Chen Yannan, Hu Yu, et al. Expression and prognosis of HJURP gene in head and neck cancer based on Oncomine Meta analysis. [J]. Journal of Chongqing Medical University 42(9):1095-1098(2017)
DOI：

Zhao Lilin, Chen Yannan, Hu Yu, et al. Expression and prognosis of HJURP gene in head and neck cancer based on Oncomine Meta analysis. [J]. Journal of Chongqing Medical University 42(9):1095-1098(2017) DOI： 10.13406/j.cnki.cyxb.001329.

摘要

目的:阐述HJURP基因(holliday junction recognition protein)在头颈部癌及正常组织中的表达及对预后影响。方法:挖掘Oncomine数据库中头颈部癌HJURP基因相关数据

并结合ArrayExpress中芯片数据集进行生存分析。结果:Oncomine数据库中

针对不同癌症

HJURP基因癌组织/正常组织表达量分析共有383个结果

其中在癌组织中显著高表达的有125个结果

低表达的仅18个结果。有13个数据集共27个分析涉及HJURP在头颈部癌组织/正常组织中的表达

其中8个分析结果显示HJURP在头颈部癌组织中显著高表达

仅一个分析结果显示其在癌组织中低表达。通过对ArrayExpress中E-TABM-302芯片数据集生存分析表明

HJURP的表达量与预后存在明显负相关性

即HJURP表达量越高

总体生存越差。结论:通过整合Oncomine芯片数据和生存相关芯片数据

首次提出HJURP在头颈部癌中高表达且对预后有不良影响

为肿瘤药物的开发提供了潜在靶点。

Abstract

Objective:To clarify expression level of holliday junction recognition protein（HJURP）in head and neck cancer and its association with prognosis. Methods:Data from Oncomine was used for HJURP expression analysis and dataset from ArrayExpress was used for survival analysis. Results:For different diseases in Oncomine

383 analysis results were found for HJURP

125 of which were significantly highly expressed in cancer tissues while only 18 of which were down regulated in cancer tissues. Thirteen datasets including twenty seven analysis were involved in head and neck cancer vs. normal for HJURP. Eight analysis showed that HJURP was up regulated and only one analysis showed the opposite result. Survival analysis was performed using E-TABM-302 dataset indicating that HJURP expression level had negative relationship with head and neck cancer prognosis. Conclusion:HJURP is up regulated in head and neck cancer by microarray analysis and can be used as a potential prognostic biomarker.

关键词

头颈部癌OncomineHJURP生存分析

Keywords

head and neck cancerOncomineholliday junction recognition proteinsurvival analysis

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