Role of metabolic inflammation and abnormal lipid distribution in the development of NAFLD

Ruan Xiongzhong

doi:10.13406/j.cnki.cyxb.001320

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Role of metabolic inflammation and abnormal lipid distribution in the development of NAFLD

更新时间：2024-01-17

- Role of metabolic inflammation and abnormal lipid distribution in the development of NAFLD
- Journal of Chongqing Medical University Vol. 42, Issue 7, Pages: 768-770(2017)
- 作者机构：
  
  重庆医科大学脂糖代谢性疾病重庆市重点实验室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.001320
  CLC： R575.5
- Published：2017，
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Ruan Xiongzhong. Role of metabolic inflammation and abnormal lipid distribution in the development of NAFLD. [J]. Journal of Chongqing Medical University 42(7):768-770(2017)
DOI：

Ruan Xiongzhong. Role of metabolic inflammation and abnormal lipid distribution in the development of NAFLD. [J]. Journal of Chongqing Medical University 42(7):768-770(2017) DOI： 10.13406/j.cnki.cyxb.001320.

摘要

代谢性炎症主要指营养物和代谢过剩所触发的

由内脏组织(主要是脂肪组织)介导的

多种细胞(包括巨噬细胞)与细胞因子共同参与的慢性低丰度性炎症反应。CD36(fatty acid translocase

cluster of differentiation 36

FAT/CD36)又名脂肪酸转运酶

被认为是将机体的天然免疫和代谢有机联合在一起的重要靶点。脂肪酸能诱导肝细胞CD36的表达

并与Toll样受体(toll-like receptors

TLR)TLR4和TLR6结合成异三聚体

促使炎症反应的发生。在代谢性炎症作用下

肝脏摄取合成脂质增加

导致非酒精性脂肪性肝病(non-alcoholic fatty liver disease

NAFLD)脂肪肝发生和发展。CD36可能成为治疗NAFLD的潜在靶点。

Abstract

Metabolic inflammation mainly refers to a chronic low abundance of inflammatory response from macrophages

adipocytes

liver and other cells triggered by excess of nutrients. CD36（cluster of differentiation 36

FAT/CD36）

also known as a fatty acid transporter

is considered to be the hub for natural immunity and lipid metabolism. Fatty acids can induce CD36 expression in hepatocytes which can bind to the Toll-like receptors（TLR）4/6 and form heterodimers

leading to occurrence of inflammatory responses. Under the metabolic inflammation

liver uptakes and synthesizes more lipids

leading to nonalcoholic fatty liver disease（NAFLD）development.CD36 may be a potential target for the treatment of NAFLD.

关键词

代谢性炎症CD36非酒精性脂肪肝

Keywords

metabolic inflammationCD36nonalchoholic fatty liver disease

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雷寒

Related Institution

Key Laboratory of Metabolism on Lipid and Glucose,Center for Lipid Research,Chongqing Medical University

Department of Clinical Center,the First Affiliated Hospital,Chongqing Medical University

重庆医科大学附属第一医院

重庆医科大学脂质代谢研究中心

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