Research progress of bone metabolism related factors and nonalcoholic fatty liver disease

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Research progress of bone metabolism related factors and nonalcoholic fatty liver disease

更新时间：2024-01-17

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- Research progress of bone metabolism related factors and nonalcoholic fatty liver disease
- Journal of Chongqing Medical University Vol. 42, Issue 7, Pages: 914-916(2017)
- 作者机构：
  
  1. 河北医科大学研究生学院
  2. 河北北方学院研究生学院
  3. 河北医科大学内科学教研室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.001309
  CLC： R575.5
- Published：2017，
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Chen Xinwei, Yu Xiaolei, Ren Luping. Research progress of bone metabolism related factors and nonalcoholic fatty liver disease. [J]. Journal of Chongqing Medical University 42(7):914-916(2017)
DOI：

Chen Xinwei, Yu Xiaolei, Ren Luping. Research progress of bone metabolism related factors and nonalcoholic fatty liver disease. [J]. Journal of Chongqing Medical University 42(7):914-916(2017) DOI： 10.13406/j.cnki.cyxb.001309.

摘要

肝脏是脂质代谢的重要器官

肝中过量的脂质堆积诱导细胞内大量活性氧的生成

引起肝细胞内质网应激、线粒体功能紊乱及脂毒性

这与非酒精性脂肪肝病发生密切相关。非酒精性脂肪肝病除引起肝脏病变及死亡外

还与2型糖尿病、动脉硬化性心脑肾血管疾病及肝外恶性肿瘤密切相关。近年来研究发现骨质疏松、骨密度减低与非酒精性脂肪肝病之间有一定的相关性

一些骨代谢相关因子在非酒精性脂肪肝病不同阶段存在异常

本文主要就骨桥蛋白、骨保护素、骨形成蛋白、骨硬化蛋白及骨膜蛋白与非酒精性脂肪肝病之间关系研究进展进行综述。

Abstract

The liver is an important organ in the lipid metabolism

excessive lipid accumulation in the liver induces the production of reactive oxygen species

leading to endoplasmic reticulum stress

mitochondrial dysfunction and lipid toxicity

which is closely related to non-alcoholic fatty liver disease（NAFLD）. NAFLD is not only associated with liver disease and death

but also closely related to type2 diabetes

atherosclerotic cardiocerebral vascular disease and extrahepatic malignant tumor. Recent studies have found that osteoporosis

bone density has certain correlation with NAFLD;some factors of bone metabolism are abnormal in different stages of NAFLD. In this paper

we will review the relationship between these factors（osteopontin

osteoprotegerin and bone morphogenetic protein

bone sclerosis and periosteal protein protein）and NAFLD.

关键词

骨代谢相关因子非酒精性脂肪肝病骨桥蛋白骨形成蛋白骨保护素骨硬化蛋白骨膜蛋白

Keywords

factors related to bone metabolismnonalcoholic fatty liver diseaseosteopontinbone morphogenetic proteinosteoprotegerinbone sclerosisperiostin protein

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