Objective:To investigate expressions of liver X receptor（LXR）in the peripheral blood mononuclear cells（PBMCs）in exudative AMD patients and to investigate their correlation with serum lipid metabolism. Methods:Twenty patients with exudative AMD and 20 age-matched healthy controls were enrolled in this study in Chongqing

China. Age

gender

serum total cholesterol（TC）

triglyceride（TG）

high density lipoprotein cholesterol（HDL）

low density lipoprotein cholesterol（LDL）levels and other medical history were also collected. Transcript levels of LXRs in PBMCs were assessed with real-time PCR between 16 AMD patients and 16 controls. PBMCs from 4 AMD patients and 4 controls were incubated with TO901317

a ligand of LXR

and then the m RNA expression of LXRs were assessed. Data were tested using a Student t test

Mann-Whitney test

Pearson correlation analysis and ROC analysis.Results:Expressions of LXRα and LXRβ were significantly decreased in PBMCs of exudative AMD group in comparison to control group（t=3.881

P=0.001;t=5.839

P=0.000）. Transcriptional responses of LXRα to the LXR agonist TO901317 was evident in both AMD and control subjects

while LXRβ was not changed. Pearson correlation analysis showed that LXRα was negatively correlated with TG

while LXRα correlated with TC

HDL

LDL

and LXRβ was not correlated with TC

TG

HDL

LDL. The ROC analysis showed that the area under the ROC curve was 0.824 for LXRα（95%CI=0.676 to 0.973

P=0.001）and 0.945 for LXRβ（95% CI=0.873 to1.000

P=0.0001）

respectively. Conclusion:LXRs in PBMCs discriminated AMD patients from controls which may be nonspecific biomarkers for exudative AMD. Furthermore

LXRs might be a target for developing novel interventions for exudative AMD.