Microglia in neural development and Alzheimer’s disease

Chen Xuan; Wang Yonghong

doi:10.13406/j.cnki.cyxb.001286

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Microglia in neural development and Alzheimer’s disease

更新时间：2024-01-17

- Microglia in neural development and Alzheimer’s disease
- Journal of Chongqing Medical University Vol. 42, Issue 6, Pages: 755-758(2017)
- 作者机构：
  
  重庆医科大学附属第一医院神经内科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.001286
  CLC： R749.16
- Published：2017，
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Chen Xuan, Wang Yonghong. Microglia in neural development and Alzheimer’s disease. [J]. Journal of Chongqing Medical University 42(6):755-758(2017)
DOI：

Chen Xuan, Wang Yonghong. Microglia in neural development and Alzheimer’s disease. [J]. Journal of Chongqing Medical University 42(6):755-758(2017) DOI： 10.13406/j.cnki.cyxb.001286.

摘要

小胶质细胞(microglia

MG)相关的神经慢性炎症一直被认为是阿尔茨海默病(Alzheimer’s disease

AD)发生的重要机制之一。近年来

MG在中枢神经系统的发育和维护中的生理功能越来越受到研究者的关注

这种非炎症功能在AD的进展中同样发挥作用

阐明MG的非炎症功能有助于更全面地理解其在AD中所起到的作用。本文就近年MG在神经系统发育和维护中的作用以及AD发生发展中的作用研究进展进行综述。

Abstract

Microglia（MG） related chronic neuroinflammation has long been considered as one of the important mechanisms of Alzheimer ’s disease（AD）. Recently

the physiological function of MG in the development and maintenance of the central nervous system has been paid more and more attention by scientists. This non-inflammatory function also plays a vital role in the progression of AD. Elucidating the non-inflammatory function of MG can be help to comprehensive understand its role in AD. This review summarizes the recent advances in the role of MG in the development and maintenance of the nervous system and the role in the development of AD.

关键词

阿尔茨海默病小胶质细胞认知障碍神经炎症

Keywords

Alzheimer’s diseasemicrogliacognitive impairmentneuroinflammation

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Related Author

Chen Xuan

Wang Yonghong

Zhou Yongli

Wang Xiaolin

Xin Gao

Bingying Du

Jingjing Chen

Xiaoying Bi

Related Institution

Department of Neurology，The First Affiliated Hospital of Naval Medical University

Experimental Teaching Management Center, Institute of Neuroscience, Chongqing Medical University

Department of Epidemiology，School of Public Health，Southern Medical University

Chongqing Institute of Medicinal Plant Cultivation， Chongqing College of Traditional Chinese Medicine

Pediatric Research Institute，National Clinical Research Center for Child Health and Disorders， Ministry of Education Key Laboratory of Child Development and Disorders，Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders， Children’s Hospital of Chongqing Medical University

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