Alterations in size of pituitary gland in patients with Alzheimer’s disease process:a preliminary MR imaging study

Guo Yi; Deng Ling; Chen Li; Liu Chen; Luo Tianyou

doi:10.13406/j.cnki.cyxb.001285

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Alterations in size of pituitary gland in patients with Alzheimer’s disease process:a preliminary MR imaging study

更新时间：2024-01-17

- Alterations in size of pituitary gland in patients with Alzheimer’s disease process:a preliminary MR imaging study
- Journal of Chongqing Medical University Vol. 42, Issue 6, Pages: 695-699(2017)
- 作者机构：
  
  1. 重庆医科大学附属第一医院放射科
  2. 重庆医科大学基础医学院解剖学教研室法医学与生物医学信息研究室
  3. 第三军医大学西南医院放射科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.001285
  CLC： R749.16;R445.2
- Published：2017，
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Guo Yi, Deng Ling, Chen Li, et al. Alterations in size of pituitary gland in patients with Alzheimer’s disease process:a preliminary MR imaging study. [J]. Journal of Chongqing Medical University 42(6):695-699(2017)
DOI：

Guo Yi, Deng Ling, Chen Li, et al. Alterations in size of pituitary gland in patients with Alzheimer’s disease process:a preliminary MR imaging study. [J]. Journal of Chongqing Medical University 42(6):695-699(2017) DOI： 10.13406/j.cnki.cyxb.001285.

摘要

目的:采用磁共振成像(magnetic resonance imaging

MRI)对阿尔茨海默病(Alzheimer’s disease

AD)发病进程中垂体大小有无变化进行初步研究。方法:采集正常对照(normal control

NC)组41例、轻度认知损害(mild cognitive impairment

MCI)组36例、AD组41例共118例受试者颅脑MRI图像

测量每例垂体前后径、宽径、高径、体积、垂体柄长径并进行标化

采用统计学方法进行组间比较。结果:垂体标化前后径MCI组大于NC组(t=3.882

P=0.000)及AD组(t=5.533

P=0.000)。垂体标化体积MCI组大于NC组(t=2.192

P=0.030)及AD组(t=2.223

P=0.028)。垂体标化宽径、标化高径及标化垂体柄长径MCI组与NC组

MCI组与AD组组间无统计学差异(P>0.05)。结论:MCI患者垂体大于正常人及AD患者

推测在AD发病进程中的MCI期可能存在垂体增大。

Abstract

Objective:To preliminarily study size alterations of pituitary gland in patients with Alzheimer’s disease（AD）process by MRI. Methods:Brain MRI scans in total of 118 subjects including 41 normal controls（NC group）

36 patients with mild cognitive impair ment（MCI group） and 41 patients with Alzheimer’s disease（AD group） were obtained. Dimensions of anteroposterior

width

height

length of the stalk of the pituitary gland and the volume were measured and standardized

and then group comparisons were statistically obtained. Results:The standardized anteroposterior diameter of the pituitary gland in MCI group were larger than that in NC group（t=3.882

P=0.000）and in AD group（t=5.533

P=0.000）. The standardized volume of the pituitary gland in MCI group were larger than in NC group（t=2.192

P=0.030）and in AD group（t=2.223

P=0.028）. There was no difference in the standardized width

height and length of the stalk of the pituitary gland between NC group and MCI group（P >0.05）

There were no differences in the standardized width

height and length of the stalk of the pituitary gland between MCI group and AD group（P>0.05）. Conclusion:The size of the pituitary gland in MCI is larger than that in NC and in AD

suggesting that the pituitary gland could increase slightly in MCI stage of AD process.

关键词

阿尔茨海默病轻度认知损害垂体磁共振成像

Keywords

Alzheimer’s diseasemild cognitive impairmentpituitary glandmagnetic resonance imaging

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