Intractable hiccup and nausea as an initial manifestations of neuromyelitis optica spectrum disorder--two cases report and review of literature

Deng Yushuang; Wang Jian

doi:10.13406/j.cnki.cyxb.001281

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Intractable hiccup and nausea as an initial manifestations of neuromyelitis optica spectrum disorder--two cases report and review of literature

更新时间：2024-01-17

- Intractable hiccup and nausea as an initial manifestations of neuromyelitis optica spectrum disorder--two cases report and review of literature
- Journal of Chongqing Medical University Vol. 42, Issue 6, Pages: 733-736(2017)
- 作者机构：
  
  成都市第二人民医院神经内科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.001281
  CLC： R744.52
- Published：2017，
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Deng Yushuang, Wang Jian. Intractable hiccup and nausea as an initial manifestations of neuromyelitis optica spectrum disorder--two cases report and review of literature. [J]. Journal of Chongqing Medical University 42(6):733-736(2017)
DOI：

Deng Yushuang, Wang Jian. Intractable hiccup and nausea as an initial manifestations of neuromyelitis optica spectrum disorder--two cases report and review of literature. [J]. Journal of Chongqing Medical University 42(6):733-736(2017) DOI： 10.13406/j.cnki.cyxb.001281.

摘要

目的:探讨以顽固性呃逆、恶心(intractable hiccup and nausea

IHN)起病的视神经脊髓炎谱系疾病(neuromyelitis optica spectrum disorders

NMOSD)临床特点。方法:分析总结2例以IHN起病的NMOSD患者的临床资料

并复习相关文献。结果:2例NMOSD患者首次发病均表现为IHN

随后在短时间内出现临床复发。其中病例1患者在2周后出现脑干症状、脊髓炎

并在半年后出现视神经炎;病例2患者在2个月后出现长节段横贯性脊髓炎(longitudinally extensive transverse myelitis

LETM)。2例患者血清水通道蛋白-4(aquaporin-4

AQP-4)抗体阳性

支持NMOSD诊断。结论:临床上以IHN起病的NMOSD诊断易被延误。

Abstract

Objective:To discuss the clinical characteristics of neuromyelitis optica spectrum disorders（NMOSD）with a first attack of intractable hiccup and nausea（IHN）. Methods:Clinical data on two patients with NOMSD with a first attack of IHN were summarized and the related literature was reviewed. Results:Both of the two cases presented IHN during the first attack of the disease

and clinical relapses occurred within a short time. In case 1

the patient developed brainstem manifestations and myelitis two weeks later and developed optic neuritis six months later. Case 2 patient relapsed and presented with longitudinally extensive transverse myelitis（LETM）two months after the first attack. Serum aquaporin-4（AQP4）antibodies were positive in both the two patients

supporting the diagno sis of NMOSD. Conclusion:NOMSD with a first attack of IHN is often diagnosed late or misdiagnosed.

关键词

呃逆视神经脊髓炎谱系疾病水通道蛋白-4抗体

Keywords

hiccupneuromyelitis optica spectrum disordersaquaporin-4 antibodies

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Related Author

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Related Institution

Department of Neurology,The First Affiliated Hospital of Chongqing Medical University

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