Evolution of diagnostic criteria of spinal cord diseases from the perspective of molecular immunopathology

Qin Xinyue; Wang Huiqi; Song Kaiyi

doi:10.13406/j.cnki.cyxb.001267

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Evolution of diagnostic criteria of spinal cord diseases from the perspective of molecular immunopathology

更新时间：2024-01-17

- Evolution of diagnostic criteria of spinal cord diseases from the perspective of molecular immunopathology
- Journal of Chongqing Medical University Vol. 42, Issue 6, Pages: 672-675(2017)
- 作者机构：
  
  重庆医科大学附属第一医院神经内科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.001267
  CLC： R744.52
- Published：2017，
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Qin Xinyue, Wang Huiqi, Song Kaiyi. Evolution of diagnostic criteria of spinal cord diseases from the perspective of molecular immunopathology. [J]. Journal of Chongqing Medical University 42(6):672-675(2017)
DOI：

Qin Xinyue, Wang Huiqi, Song Kaiyi. Evolution of diagnostic criteria of spinal cord diseases from the perspective of molecular immunopathology. [J]. Journal of Chongqing Medical University 42(6):672-675(2017) DOI： 10.13406/j.cnki.cyxb.001267.

摘要

视神经脊髓炎(optic nerve myelitis

NMO)是区别于多发性硬化(multiple sclerosis

MS)的神经系统炎性脱髓鞘性疾病。由于特异性水通道蛋白-4(aquaporin-4

AQP4)抗体的发现

人们对NMO有了崭新的认识和理解

并提出了视神经脊髓炎谱系疾病(neuromyelitis optica spectrum disorders

NMOSDs)的概念。最近研究发现髓鞘少突胶质细胞糖蛋白(myelin oligodendrocyte glycoprotein

MOG)作为新的靶抗原

在血清AQP4抗体阴性患者中有很大意义。本研究根据分子免疫病理学的新发现、专家共识结合临床经验解读NMOSDs国际诊断标准

对NMOSDs的诊断和治疗提出一些意见。

Abstract

Optic nerve myelitis（NMO）is an inflammatory demyelinating disease of the central nervous system（CNS）that differs from multiple sclerosis（MS）. With the discovery of NMO highly specific the aquaporin-4（AQP4）antibody

the understanding of NMO has been changed fundamentally

and the concept of neuromyelitis optica spectrum disorders（NMOSDs）is proposed. Recently

it has been found that myelin oligodendrocyte glycoprotein（MOG）

as a new target antigen

is of great significance in patients with negative AQP4 antibody. In this paper

according to the new findings of molecular immunology

expert consensus and clinical experience

we can interpret the NMOSDs international diagnostic criteria

and give some advice on the diagnosis and treatment of NMOSDs.

关键词

视神经脊髓炎谱系疾病诊断标准水通道蛋白质-4髓鞘少突胶质细胞糖蛋白

Keywords

neuromyelitis optica spectrum disordersdiagnostic criteriaaquaporin-4myelin oligodendrocyte glycoprotein

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