Research progresses of the relationship between dioxygenases in kynurenine pathway and tumor

Ni Xiaolin; Hu Runhui; He Chen; Xu Yiqing; Yu Chengpeng; Zhu Zhengming

doi:10.13406/j.cnki.cyxb.001251

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Research progresses of the relationship between dioxygenases in kynurenine pathway and tumor

更新时间：2024-01-17

- Research progresses of the relationship between dioxygenases in kynurenine pathway and tumor
- Journal of Chongqing Medical University Vol. 42, Issue 11, Pages: 1363-1365(2017)
- 作者机构：
  
  1. 南昌大学第二临床医学院
  2. 南昌大学第二附属医院胃肠外科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.001251
  CLC： R730.2
- Published：2017，
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Ni Xiaolin, Hu Runhui, He Chen, et al. Research progresses of the relationship between dioxygenases in kynurenine pathway and tumor. [J]. Journal of Chongqing Medical University 42(11):1363-1365(2017)
DOI：

Ni Xiaolin, Hu Runhui, He Chen, et al. Research progresses of the relationship between dioxygenases in kynurenine pathway and tumor. [J]. Journal of Chongqing Medical University 42(11):1363-1365(2017) DOI： 10.13406/j.cnki.cyxb.001251.

摘要

犬尿氨酸途径代谢酶是一类含亚铁血红素的蛋白酶

能够将色氨酸催化成犬尿氨酸

造成色氨酸的减少和犬尿氨酸及其下游代谢产物大量累积

从而抑制T细胞增殖。越来越多的研究表明

这条途径在肿瘤的转移过程中扮演了重要的角色

然而目前关于这条途径与肿瘤关系的综述却很少

因此将回顾犬尿氨酸途径代谢酶与肿瘤的研究进展进行综述。此综述将阐述3种犬尿氨酸途径代谢酶的生物功能及其与肿瘤的关系

并且提供关于这个领域的未来发展方向

尤其是3种犬尿氨酸途径代谢酶抑制剂的研究发展及应用。

Abstract

Dioxygenases in kynurenine pathway are heme-protein enzymes. These enzemyes could catalyze tryptophan into kynurenine

resulting in the decrease of tryptophan and the increase of kynurenine and its downstream products

which could inhibit the proliferation of T cells. Nowadays

increasing evidence demonstrate kynurenine pathwway plays an important role in the metastasis of tumor. However

there is little reviews about it. Hence

we will review the researches about the relationship between dioxygenases in kynurenine pathway and tumor. This paper will illustrate the biologic function of these enzymes and their relationship with tumor

providing an opinion regarding the future developmental directions of this region

especially the development and applications of these enzymes inhibitors as treatments.

关键词

肿瘤色氨酸代谢吲哚胺-23-加氧酶1吲哚胺-23-加氧酶2色氨酸-23-双加氧酶

Keywords

tumortryptophan metabolismindoleamine 23-dioxygenase 1indoleamine 23-dioxygenase 2tryptophan-23-dioxy genase

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