Objective:To determine the role of stathmin in the pathogenesis of chronic itch caused by inflammatory skin diseases in human subjects. Methods:This research collected 35 samples from patients with chronic itch caused by inflammatory skin diseases and 3 control samples. Expression of stathmin was evaluated in skin biopsy samples from patients and control individuals by means of immunohistochemistry（IHC）. Hematoxylin-eosin（HE）staining was used to detect structural changes in epidermal tissue from patients.Results:IHC showed that high expressions of stathmin were found on keratinocytes

epithelial cells and inflamed immune cells in skin lesions from patients compared with those of control individuals. HE showed that the stratum corneum of skin lesions from patients thickened accompanied with hyperkeratosis and inflammatory cell infiltration. Conclusion:Stathmin plays a role in the pathogenesis of chronic itch. Stathmin produced by keratinocytes

epithelial cells and inflamed immune cells can affect the skin barrier function

and promote the chronic itch process. Stathmin may be a promising target for chronic itch treatment

and its expression would be significant for the development of new drugs and a better treatment.