Mechanism of embolism in patients with dilated cardiomyopathy and progress on its prevention and treatment

Yang Lili; Zhang Xiaogang

doi:10.13406/j.cnki.cyxb.001202

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Mechanism of embolism in patients with dilated cardiomyopathy and progress on its prevention and treatment

更新时间：2024-01-17

- Mechanism of embolism in patients with dilated cardiomyopathy and progress on its prevention and treatment
- Journal of Chongqing Medical University Vol. 42, Issue 5, Pages: 613-617(2017)
- 作者机构：
  
  重庆医科大学附属第一医院心血管内科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.001202
  CLC： R542.2
- Published：2017，
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Yang Lili, Zhang Xiaogang. Mechanism of embolism in patients with dilated cardiomyopathy and progress on its prevention and treatment. [J]. Journal of Chongqing Medical University 42(5):613-617(2017)
DOI：

Yang Lili, Zhang Xiaogang. Mechanism of embolism in patients with dilated cardiomyopathy and progress on its prevention and treatment. [J]. Journal of Chongqing Medical University 42(5):613-617(2017) DOI： 10.13406/j.cnki.cyxb.001202.

摘要

扩张型心肌病(dilated cardiomyopathy

DCM)患者心腔内血栓发生率及临床血栓栓塞事件发生率均较高。心腔内血栓形成与多种因素有关

如心脏扩大、心内膜面改变、心肌运动减弱、血流淤滞、心律失常、血液高凝状态等。目前针对扩张型心肌病患者加用抗凝剂治疗的专家建议是:左心室射血分数(left ventricular ejection fraction

LVEF)<30%

有栓塞表现的病史

或超声心动图发现附壁血栓形成。心脏扩大患者有报道把阿司匹林或阿司匹林联合水蛭素类药等纳入常规治疗方案

合并房颤(atrial fibrillation

AF)则加用华法林或新型口服抗凝药(novel oral anticoagulants

NOACs)治疗

本文仅对扩张型心肌病患者栓塞风险流行病学、发生机制和防治进行综述。

Abstract

Patients with dilated cardiomyopathy（DCM）have higher incidence of heart lumen thrombosis and clinical thromboembolic events. Heart lumen thrombosis relates to many factors

including cardiac dilatation

the endocardial surface change

myocardial motion decreases

blood flow congestion

arrhythmia

blood high condensation state

etc. Now

the expert advice for adding anticoagulant therapy for patients with DCM is:left ventricular ejection fraction<30%

having a history of embolism performance

or mural thrombus formation in echocardiography. There were articles reported using aspirin

or by a combination of aspirin and hirudin drugs as conventional treatment for patients with cardiomegaly;some reported adding warfarin or new oral anticoagulants if cardiomegaly complicated with atrial fibrillation. This article reviewed the epidemiology

mechanism and prevention and cure for risk patients with DCM.

关键词

扩张型心肌病血栓栓塞抗栓

Keywords

dilated cardiomyopathyblood clotsEmbolismanti-thrombus

references

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Department of Cardiology,the Children’s Hospital,Chongqing Medical University

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