Roles of exosomes in the communication of central nervous system cells

Zhao Peiyuan; Wang Lei

doi:10.13406/j.cnki.cyxb.001201

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Roles of exosomes in the communication of central nervous system cells

更新时间：2024-01-17

- Roles of exosomes in the communication of central nervous system cells
- Journal of Chongqing Medical University Vol. 42, Issue 10, Pages: 1219-1222(2017)
- 作者机构：
  
  首都医科大学中医药学院、中医络病研究北京市重点实验室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.001201
  CLC： R338
- Published：2017，
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Zhao Peiyuan, Wang Lei. Roles of exosomes in the communication of central nervous system cells. [J]. Journal of Chongqing Medical University 42(10):1219-1222(2017)
DOI：

Zhao Peiyuan, Wang Lei. Roles of exosomes in the communication of central nervous system cells. [J]. Journal of Chongqing Medical University 42(10):1219-1222(2017) DOI： 10.13406/j.cnki.cyxb.001201.

摘要

中枢神经系统的功能有赖于神经细胞之间的相互通讯。最近的研究表明这些细胞能够分泌直径为40

00 nm的囊泡

即外泌体。外泌体可以携带蛋白质、RNA、miRNA等多种物质

其功能及内容物因细胞类型及细胞所处状态而有差异

可以介导细胞间的通讯而无须细胞间直接接触。中枢神经系统的发育、功能的完整性、神经细胞的存活均与外泌体运输的生物活性分子有关。本研究阐述了外泌体的一般特性及其在中枢神经细胞间通讯中的作用。

Abstract

The function of central nervous system（CNS）relies on intercellular communication between neural cells. Recent studies have shown these cells release nanovesicles called exosomes

generally 40 to 100 nm in diameter. They contain proteins

RNAs and lipids. The biological effects and cargos of exosomes can be various depending on the types and conditions of cells. Exosomes can mediate intercellular signaling without requiring direct contact between cells. The development of CNS

integrity of neuron function involve in the bioactive molecules that packed into exosomes. Here the properties of exosomes and the roles of exosomes in cell-to-cell communication of CNS are discussed.

关键词

外泌体中枢神经系统细胞间通讯

Keywords

exosomescentral nervous systemcommunication of cells

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Related Institution

Department of Urology,the First Affiliated Hospital of Chongqing Medical University

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