Lu Li, Wei Fei, Tang Jie, et al. Comparative study of different antiplatelet therapeutic regimens after cerebral artery stenting. [J]. Journal of Chongqing Medical University 42(10):1253-1257(2017)
DOI:
Lu Li, Wei Fei, Tang Jie, et al. Comparative study of different antiplatelet therapeutic regimens after cerebral artery stenting. [J]. Journal of Chongqing Medical University 42(10):1253-1257(2017) DOI: 10.13406/j.cnki.cyxb.001196.
Comparative study of different antiplatelet therapeutic regimens after cerebral artery stenting
Objective:To compare the efficacy and adverse events of dual antiplatelet drugs in different durations and single antiplatelet drug for patients after cerebral artery stenting. Methods:The experiment is a investigative and retrospective study
and 380 patients were admitted. According to the durations of dual antiplatelet(aspirin and clopidogrel)after cerebral artery stenting
the patients were divided into three groups:group A(60 cases)for 1month
the group B(220 cases)for 3 months
group C(100 cases)for 4 to 12 months. According to the different single antiplatelet drugs after dual antiplatelet regimen
the patients of group A and group B were divided into two subgroups:AB1 group(132cases)for aspirin
AB2(91 cases)for clopidogrel. By chi-square test or Fisher’s exact test and multifactor Logistic regression analysis
the recurrence incidence of cerebral infarction
cerebral hemorrhage
extracranial blood
myocardial infarction
death within 1 year after cerebral artery stenting were compared. Results:There was no significant difference in the incidence of cerebral infarction recurrence(P=0.580)among group A
B
C;and no statistical difference(P=1.000)between group AB1 and AB2. There was no statistical differences in myocardial infarction
cerebral hemorrhage and extracranial blood
death among group A
B
C and between group AB1
AB2. Conclusion:Taking aspirin and clopidogrel together for 1month
3 months
and 4 to 12 months has the same effect
the same as taking aspirin or clopidogrel alone after dual antiplatelet.