Diabetic foot（DF）is a common and severe complication

with an incidence of 15% to 25% in diabetic population. Among these patients with DF

50% are accompanied with wound infection. There are multiple risk factors which affect DF prognosis including peripheral arterial disease

proportion and depth of ulcer

peripheral neuropathy and infection. Therefore

DF is the main cause of amputation for clustering risk factors. Meanwhile

DF may also lead to increasing risk of cardiovascular events and all-cause mortality.So

prevention and treatment of DF is vital in improving living quality and survival time of diabetic patients. Although progress have been made in DF treatment

current therapies are still shortened in resolving clinic challenges

and exploring new treatment for DF is urgently needed. For the purpose

advance in diagnosis

assessment and therapy were summarized.