Research progress of autophagy in lung inflammatory diseases

Duan Yushan; Liu Qiong

doi:10.13406/j.cnki.cyxb.001156

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Research progress of autophagy in lung inflammatory diseases

更新时间：2024-01-17

- Research progress of autophagy in lung inflammatory diseases
- Journal of Chongqing Medical University Vol. 42, Issue 1, Pages: 7-10(2017)
- 作者机构：
  
  重庆医科大学附属第一医院急诊医学科&重症医学科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.001156
  CLC： R56
- Published：2017，
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[1]段玉珊,刘琼.自噬在肺部炎症性疾病中的研究新进展[J].重庆医科大学学报,2017,42(01):7-10.

Duan Yushan, Liu Qiong. Research progress of autophagy in lung inflammatory diseases. [J]. Journal of Chongqing Medical University 42(1):7-10(2017)
[1]段玉珊,刘琼.自噬在肺部炎症性疾病中的研究新进展[J].重庆医科大学学报,2017,42(01):7-10. DOI： 10.13406/j.cnki.cyxb.001156.

Duan Yushan, Liu Qiong. Research progress of autophagy in lung inflammatory diseases. [J]. Journal of Chongqing Medical University 42(1):7-10(2017) DOI： 10.13406/j.cnki.cyxb.001156.

摘要

自噬（autophagy）是细胞生物的一种基本特征

具有独特的调控通路

它可以选择性地降解特定的蛋白质、细胞器以及入侵的细菌。一般认为在病理生理状态下

自噬是一种细胞的保护性反应。近期研究发现在某些代谢性疾病、神经退行性病变、感染及免疫等疾病中自噬却发挥不同作用

在某些疾病中

抑制自噬会导致疾病加重

而某些疾病则反之

自噬的激活会导致疾病的发生发展。那么自噬在肺部炎症疾病中有着什么样的作用呢?本文就自噬在肺部炎症性疾病中的研究新进展作一综述。

Abstract

Autophagy is a basic feature of cell biology

with a unique regulatory pathway

which can selectively degrade specific proteins

organelles

and invade bacteria. It is generally believed that autophagy is a protective reaction of cells in the pathological and physiological state. Recent studies have shown that in certain metabolic disorders and other neurodegenerative diseases

infection and immunity diseases autophagy play a different role. In certain diseases

inhibition of autophagy can lead to an exacerbation of the disease;and in certain diseases

vice versa

autophagy activation can lead to disease occurrence and development. So what kind of role does autophagy have in lung inflammatory disease? This article reviews the progress in the research of autophagy in lung inflammatory diseases.

关键词

自噬肺部炎症性疾病慢性阻塞性肺疾病哮喘免疫性肺炎肺结核肺癌急性肺损伤

Keywords

autophagypulmonary inflammatory diseasechronic obstructive pulmonary diseaseasthmaimmune pneumoniapulmonary tuberculosislung canceracute lung injury

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