Objective:To investigate the diagnosis value of serum tumor markers cytokeratin 19 fragment（Cyfra 21-1）

squamous cell carcinoma antigen（SCCAg）

Ferritin

carcino-embryonic antigen（CEA）

carbohydrate antigen（CA19-9）and α-fetoprotein（AFP）for patients with oral/oropharyngeal squamous cell carcinomas（OSCC/OPSCC）. Methods:This study had involved in 169 patients with OSCC/OPSCC as experimental group

86 patients with oral benign tumor as control group

and 30 healthy people as normal control group. The pre-treatment serum levels of Cyfra 21-1

SCCAg

Ferritin

CEA

CA19-9

and AFP were detected by electro chemiluminescence immunoassay（ECLIA）

and then calculated with a receiver operating characteristic（ROC） curve. Results:The serum Cyfra21-1

SCCAg

Ferritin and CEA levels of OSCC/OPSCC group were significantly higher than those of control group and healthy group（all P<0.05）

while there was no significant difference in serum CA19-9 and AFP levels among the three groups（all P>0.05）. The serum Cyfra 21-1 level of patients with early stage OSCC/OPSCC（Ⅰ+Ⅱphase）was significantly higher than that of control group and healthy group（all P<0.05）

but there was no significant difference in serum SCCAg

Ferritin

CEA

CA19-9 and AFP levels among the three groups（all P >0.05）. Serum Cyfra21-1

SCCAg

Ferritin and CEA levels of patients with middle-late OSCC/OPSCC（Ⅲ+Ⅳphase）were significantly higher than that of early OSCC/OPSCC

control group and healthy group（all P<0.05）. The area under the ROC curve of Cyfra 21-1 was the largest

while areas under the ROC curve of SCCAg

CEA and Ferritin decreased in turn（the AUC were 0.748

0.708

0.669

0.627 respectively

and the 95% CI were 0.692 to 0.805

0.647 to 0.768

0.605 to 0.733

0.561 to 0.692 respectively）;the diagnostic cut-off level of Cyfra 21-1 was 2.17 ng/m L

and the sensitivity and specificity was 60.36% and 81.03% . The higher the differentiation degree of oral/oropharyngeal squamous cell carcinomas

the lower the serum level of Cyfra 21-1（rs=-0.223

P=0.004）. Conclusion:In the six kinds of serum tumor markers above

serum Cyfra 21-1 and SCCAg are superior to other markers in diagnosing OSCC/OPSCC. At the same time Cyfra 21-1 had better diagnosis value for OSCC/OPSCC at early stage

whlie CA19-9 and AFP don’t.