Association between norepinephrine transporter T182C polymorphism and depression:a Meta-analysis

Wang Hanyan; Liu Jing; Deng Zhilin; Liu Wenqin

doi:10.13406/j.cnki.cyxb.001128

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Association between norepinephrine transporter T182C polymorphism and depression:a Meta-analysis

更新时间：2024-01-17

- Association between norepinephrine transporter T182C polymorphism and depression:a Meta-analysis
- Journal of Chongqing Medical University Vol. 42, Issue 10, Pages: 1281-1287(2017)
- 作者机构：
  
  1. 川北医学院基础医学院生物化学教研室
  2. 川北医学院影像系
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.001128
  CLC： R749.4
- Published：2017，
扫描看全文
Wang Hanyan, Liu Jing, Deng Zhilin, et al. Association between norepinephrine transporter T182C polymorphism and depression:a Meta-analysis. [J]. Journal of Chongqing Medical University 42(10):1281-1287(2017)
DOI：

Wang Hanyan, Liu Jing, Deng Zhilin, et al. Association between norepinephrine transporter T182C polymorphism and depression:a Meta-analysis. [J]. Journal of Chongqing Medical University 42(10):1281-1287(2017) DOI： 10.13406/j.cnki.cyxb.001128.

摘要

目的:采用Meta分析探讨去甲肾上腺素转运体（norepinephrine transporter

NET）T182C基因多态性与抑郁症易感性之间的关系。方法:通过检索Pub Med、Embase、万方数据库、维普中文科技期刊数据库、中国知网（Chinese National Knowledge Infrastructure

CNKI）数据库

获取相关研究

提取有效数据后

采用STATA 12.0进行统计分析。评价指标采用比值比（odds ratio

OR）、95%可信区间（confidence interval

CI）与P值

计算4种不同遗传模型下T182C基因多态性与抑郁症发病风险的关联性。结果:共检索出12篇符合标准的文献进入Meta分析

包括病例组3 056例

对照组2 861例。在等位（OR=1.15

95%CI=1.04

.28

P=0.009）、共显性（OR=1.41

95%CI=1.04

.90

P=0.026）、隐性（OR=1.44

95%CI=1.13

.85

P=0.004）3种遗传模式下T182C位点多态性与抑郁症易感性的关系具有统计学意义

且等位基因C或基因型CC增加抑郁症发病风险。亚组分析发现采用不同的评价量表是异质性的主要来源。结论:NET T182C基因多态性与抑郁症的发生有关

等位基因C是导致抑郁症发生的一个潜在危险因素。

Abstract

Objective:To explore the association between norepinephrine transporter（NET）T182C polymorphism and depression by carrying out a meta-analysis based on published articles. Methods:Databases including Pub Med

Embase

Wan Fang（Chinese）

CNKI and CQVIP were searched for literature about norepinephrine transporter T182 C polymorphism and depression

and the data were analyzed by using STATA 12.0. OR

95% CI and P value were employed as the evaluation index to assess the association between T182 C polymorphism and risk of depression under four different genetic models. Results:Twelve studies of 3 056 cases and 2 861 controls meeting the inclusion criteria were enrolled in the Meta-analysis that. Significant association was observed between NET T182 C polymorphism and depression under allelotype model（OR=1.15

95%CI=1.04 to 1.28

P=0.009）

co-dominant model（OR=1.41

95%CI=1.04 to 1.90

P=0.026）

recessive model（OR=1.44

95%CI=1.13 to 1.85

P=0.004）;allele C or genotype CC increased the risk of depression. The sub-group analysis showed that employing the different evaluation scales for depression mainly resulted in the heterogeneity. Conclusion:NET T182 C polymorphism is related to the depression

and allele C may contribute to the risk of major depressive disorder.

关键词

去甲肾上腺素转运体T182C多态性抑郁症Meta分析

Keywords

norepinephrine transporterT182CpolymorphismdepressionMeta-analysis

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