Cardioprotection of heat shock protein 22 from the perspective of mitochondrial protection

Zeng Shengqiang; Wu Yanqing

doi:10.13406/j.cnki.cyxb.001119

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Cardioprotection of heat shock protein 22 from the perspective of mitochondrial protection

更新时间：2024-01-17

- Cardioprotection of heat shock protein 22 from the perspective of mitochondrial protection
- Journal of Chongqing Medical University Vol. 41, Issue 12, Pages: 1250-1253(2016)
- 作者机构：
  
  南昌大学第二附属医院心血管内科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.001119
  CLC： R54
- Published：2016，
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[1]曾圣强,吴延庆.从保护线粒体角度谈热休克蛋白22的心肌保护作用[J].重庆医科大学学报,2016,41(12):1250-1253.

Zeng Shengqiang, Wu Yanqing. Cardioprotection of heat shock protein 22 from the perspective of mitochondrial protection. [J]. Journal of Chongqing Medical University 41(12):1250-1253(2016)
[1]曾圣强,吴延庆.从保护线粒体角度谈热休克蛋白22的心肌保护作用[J].重庆医科大学学报,2016,41(12):1250-1253. DOI： 10.13406/j.cnki.cyxb.001119.

Zeng Shengqiang, Wu Yanqing. Cardioprotection of heat shock protein 22 from the perspective of mitochondrial protection. [J]. Journal of Chongqing Medical University 41(12):1250-1253(2016) DOI： 10.13406/j.cnki.cyxb.001119.

摘要

线粒体是真核生物细胞内能量代谢和信号转导的关键细胞器。线粒体功能障碍会导致ATP合成障碍和氧化呼吸链结构异常

与许多疾病的发生发展存在密切联系。热休克蛋白22（heat shock protein 22

HSP22）属于小分子热休克蛋白超家族成员之一。哺乳动物心肌在各种应激（如缺血、压力超负荷）情况下

可诱导其表达上调并通过调节线粒体功能发挥促进心肌生存及维持心肌功能等重要心肌保护作用。因此

HSP22有望成为治疗以线粒体功能障碍为病理学基础疾病的潜在途径。同时

HSP22在延缓心脏衰老中可能发挥重要作用。本文从保护线粒体功能方面综述在各种病理生理情况下HSP22的心肌保护作用。

Abstract

Mitochondria are critical organelles of energy metabolish and signal transduction in eukaryotes. Mitochondrial dysfunction leads to impaired ATP generation and structural alterations of the respiratory chain

which closely relates to the development and progression of many diseases. Heat shock protein 22(HSP22)is a member of the superfamily of small heat shock proteins. HSP22

upregulated by various conditions of mammalian myocardial stress

such as ischemia and cardiac overload

plays a critical role of promoting myocardial survival and maintaining myocardial function. Therefore

HSP22 may be a new potential treatment of diseases whose etiology is based upon dysfunction of mitochondria. Meanwhile

HSP22 may play a vital role in slowing down cardiac aging. We review the cardioprotection of HSP22 under physiological and pathological conditions from mitochondrial protection perspective.

关键词

热休克蛋白22线粒体心肌保护衰老

Keywords

heat shock protein 22mitochondriamyocardial protectionaging

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