Comparison of clinical characteristics of necrotizing enterocolitis between pre-term and full-term neonates

Liu Li; Li Qiuyu; An Yao; Ran Yalin; Li Luquan

doi:10.13406/j.cnki.cyxb.001091

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Comparison of clinical characteristics of necrotizing enterocolitis between pre-term and full-term neonates

更新时间：2024-01-17

- Comparison of clinical characteristics of necrotizing enterocolitis between pre-term and full-term neonates
- Journal of Chongqing Medical University Vol. 42, Issue 8, Pages: 1006-1010(2017)
- 作者机构：
  
  重庆医科大学附属儿童医院新生儿诊治中心儿童发育疾病研究教育部重点实验室儿童发育重大疾病国家国际科技合作基地儿科学重庆市重点实验室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.001091
  CLC： R722.1
- Published：2017，
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[1]刘利,李秋宇,安瑶,冉亚林,李禄全.早产与足月新生儿坏死性小肠结肠炎临床对比分析[J].重庆医科大学学报,2017,42(08):1006-1010.

Liu Li, Li Qiuyu, An Yao, et al. Comparison of clinical characteristics of necrotizing enterocolitis between pre-term and full-term neonates. [J]. Journal of Chongqing Medical University 42(8):1006-1010(2017)
[1]刘利,李秋宇,安瑶,冉亚林,李禄全.早产与足月新生儿坏死性小肠结肠炎临床对比分析[J].重庆医科大学学报,2017,42(08):1006-1010. DOI： 10.13406/j.cnki.cyxb.001091.

Liu Li, Li Qiuyu, An Yao, et al. Comparison of clinical characteristics of necrotizing enterocolitis between pre-term and full-term neonates. [J]. Journal of Chongqing Medical University 42(8):1006-1010(2017) DOI： 10.13406/j.cnki.cyxb.001091.

摘要

目的:对比分析早产与足月新生儿坏死性小肠结肠炎（neonatal necrotizing enterocolitis

NEC）的临床特点。方法:回顾性分析338例NEC临床资料

比较患儿围产期相关信息、NEC诊断后并发症、治疗情况及预后危险因素。结果:早产组94例

足月组244例

早产组胎膜早破发生率高于足月组;早产组NEC诊断后并发败血症、呼吸衰竭高于足月组;早产组NEC诊断后多巴胺、IVIG使用率及输注红细胞高于足月组（均P

0.05）。logistic回归分析发现

影响早产组预后不良的危险因素为Ⅲ期NEC（OR=6.725

95%CI=2.153

1.01

P=0.001）及并发败血症（OR=3.78

95%CI=1.204

1.873

P=0.023）;足月组为Ⅲ期NEC（OR=7.762

95%CI=3.392

5.23

P=0.000）。结论:NEC在早产、足月儿人群发病的围产期因素、并发症、预后危险因素方面存在差异

早产儿并发症更多。Ⅲ期NEC是导致患儿预后不良的共同危险因素

并发败血症是导致早产患儿预后不良的额外危险因素。

Abstract

Objective:To compare clinical characteristics of necrotizing enterocolitis(NEC)between pre-term and full-term neonates.Methods:Clinical data of 338 patients diagnosed as NEC(Bell’s stage ≥2) were retrospectively analyzed. Data including perinatal information

complications after NEC diagnosed

basic treatment after NEC diagnosed and risk factors of prognosis were compared between pre-term group(n=94)and term group(n=224). Results:The incidence of premature rupture of membranes was higher in preterm group(P<0.05);sepsis

respiratory failure were more likely happen in neonates after NEC diagnosed in pre-term group(P<0.05)

and rate of using dopamine

IVIG and infusion of red blood cells were higher in pre-term group(P<0.05). Logistic regression analysis discovered that risk factors for mortality in pre-term infants were sepsis(OR=3.78

95%CI=1.204 to 11.873

P=0.023)and NEC stageⅢ(OR=6.725

95%CI=2.153 to 21.01

P=0.001). While

the risk factors in full-term group were NEC stage Ⅲ(OR=7.762

95%CI=3.392 to 15.23

P=0.000). Conclusion:There are differences in prenatal factors

clinical complications

treatment measures and risk factors affecting prognosis between pre-term infants and full-term infants with NEC. Pre-term NEC patients have more complications than full-term infants. Sepsis and NEC stage Ⅲ are common risk factors for poor prognosis of pre-term and full-term NEC patients.Sepsis is an extra risk factor for poor prognosis of pre-term NEC patients.

关键词

早产儿足月儿坏死性小肠结肠炎临床对比分析

Keywords

preterm infantsterm infantsnecrotizing enterocolitisclinical comparative analysis

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Related Institution

Department of Neonatal Diagnosis and Treatment Center，Children’s Hospital of Chongqing Medical University/Ministry of Education Key Laboratory of Child Development and Disorders/China International Science and Technology Cooperation Base of Child Development and Critical Disorders/Chongqing Key Laboratory of Pediatrics

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Department of Neonatology，the Children’s Hospital，Chongqing Medical University

Department of Neonate，the Children’s Hospital，Chongqing Medical University

Department of Neurology，the Children’s Hospital，Chongqing Medical University，Ministry of Education Key Laboratory of Child Development and Disorders，Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders

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