Association of serum irisin and insulin resistant in female with polycystic ovary syndrome

Yang Ruomei; Wei Xiao; Wang Chengpan; Li Zhiyong; Tang Qian; Huang Dan; Yang Gangyi; Li Ling

doi:10.13406/j.cnki.cyxb.001064

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Association of serum irisin and insulin resistant in female with polycystic ovary syndrome

更新时间：2024-01-17

- Association of serum irisin and insulin resistant in female with polycystic ovary syndrome
- Journal of Chongqing Medical University Vol. 41, Issue 11, Pages: 1163-1167(2016)
- 作者机构：
  
  1. 重庆医科大学附属永川医院内分泌科
  2. 重庆医科大学附属第二医院内分泌科
  3. 重庆医科大学检验医学院临床检验诊断学教育部重点实验室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.001064
  CLC： R711.75
- Published：2016，
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[1]杨若梅,魏晓,王成潘,李志勇,唐倩,黄丹,杨刚毅,李伶.多囊卵巢综合征患者血清鸢尾素水平及其与胰岛素抵抗的关系[J].重庆医科大学学报,2016,41(11):1163-1167.

Yang Ruomei, Wei Xiao, Wang Chengpan, et al. Association of serum irisin and insulin resistant in female with polycystic ovary syndrome. [J]. Journal of Chongqing Medical University 41(11):1163-1167(2016)
[1]杨若梅,魏晓,王成潘,李志勇,唐倩,黄丹,杨刚毅,李伶.多囊卵巢综合征患者血清鸢尾素水平及其与胰岛素抵抗的关系[J].重庆医科大学学报,2016,41(11):1163-1167. DOI： 10.13406/j.cnki.cyxb.001064.

Yang Ruomei, Wei Xiao, Wang Chengpan, et al. Association of serum irisin and insulin resistant in female with polycystic ovary syndrome. [J]. Journal of Chongqing Medical University 41(11):1163-1167(2016) DOI： 10.13406/j.cnki.cyxb.001064.

摘要

目的:探讨多囊卵巢综合征（polycystic ovarian syndrome

PCOS）患者血清鸢尾素（irisin）水平及其与胰岛素抵抗（insulin resistance

IR）的关系。方法:纳入PCOS患者60例及健康女性志愿者80例

测量血清激素、血清鸢尾素浓度等

用HOMA稳态模型抵抗指数评估IR

胰岛β细胞功能指数（HOMA-β）、口服葡萄糖耐量试验（oral glucose tolerance test

OGTT）30 min胰岛素血糖与空腹胰岛素血糖差值的比（△Ins30/△Glu30）、胰岛素与血糖比值曲线下面积（AUCIns/Glu）评估β细胞功能

以及采用Pearson’s相关和多元逐步线性回归分析血清鸢尾素与IR的关系。结果:PCOS患者血清鸢尾素较对照组升高（P<0.05）;血清鸢尾素水平与体质指数（r=0.381

P=0.003）、空腹血糖（r=0.565

P=0.000）、空腹胰岛素（r=0.551

P=0.000）、餐后2 h胰岛素（r=0.299

P=0.020）、LH/FSH（r=0.802

P=0.000）、孕酮（r=0.349

P=0.006）、TG（r=0.306

P=0.018）、HOMA-IR（r=0.632

P=0.000）、AUCIns/Glu（r=0.317

P=0.014）呈正相关;多元逐步回归分析显示PCOS患者血清鸢尾素与HOMA-IR相关

与β细胞功能（HOMA-β

△Ins30/△Glu30

AUCIns/Glu）无相关（F=169.05

R2=0.945

P=0.00）。结论:PCOS患者血清鸢尾素水平升高

可能在IR的发病机制中起作用。

Abstract

Objective:To investigate the serum irisin levels and its association with insulin resistance(IR)in patients with polycystic ovary syndrome(PCOS). Methods:Sixty patients diagnosed as PCOS and eighty healthy female volunteers were enrolled in this study.Serum hormone and irisin levels were measured. Homeostasis model of insulin resistance(HOMA-IR)was performed to evaluate IR

and HOMA-β

△Ins30/△Glu30

AUCIns/Gluwere used to assess β-cell function

and the relation between irisin and IR was analyzed by Pearson’s correlation and multiple stepwise regression. Results:The level of serum irisin in patients with PCOS was higher than that of control group(P<0.05). Serum irisin levels were positively correlated with BMI(r=0.381

P=0.003)

fasting blood glucose(r=0.565

P=0.000)

fasting insulin(r=0.551

P=0.000)

2-hour post-load insulin(r =0.299

P =0.020)

LH/FSH(r =0.802

P =0.000)

progesterone(r=0.349

P=0.006)

TG(r=0.306

P=0.018)

HOMA-IR(r=0.632

P=0.000)and AUCIns/Glu(r=0.317

P=0.014). Multiple stepwise regression analysis indicated that irisin was associated with HOMA-IR

but had no correlation with β-cell function(HOMA-β

△Ins30/△Glu30

AUCIns/Glu)in PCOS patients(F=169.05

R2=0.945

P=0.000). Conclusion:Serum irisin is elevated in patients with PCOS and may play a role in the pathogenesis of IR.

关键词

多囊卵巢综合征鸢尾素胰岛素抵抗

Keywords

polycystic ovarian syndromeirisininsulin resistance

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Related Author

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Related Institution

Department of Endocrinology，People’s Hospital of Changshou Chongqing

Department of Endocrinology，The Second Affiliated Hospital of Chongqing Medical University

School of Medical Laboratory，Weifang Medical University

Cheeloo College of Medicine，Shandong University

Department of Laboratory Medicine，The First Affiliated Hospital of Shandong First Medical University/Shandong Provincial Qianfoshan Hospital，Shandong Provincial Medicine and Health Key Laboratory of Clinical Laboratory Diagnostics

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