Research progress of a new anti-diabetic agent:SGLT2 inhibitors

Xiong Xin; Long Min; Cai Leiqin; Zheng Hongting

doi:10.13406/j.cnki.cyxb.001056

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Research progress of a new anti-diabetic agent:SGLT2 inhibitors

更新时间：2024-01-17

- Research progress of a new anti-diabetic agent:SGLT2 inhibitors
- Journal of Chongqing Medical University Vol. 41, Issue 11, Pages: 1172-1176(2016)
- 作者机构：
  
  第三军医大学附属新桥医院内分泌科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.001056
  CLC： R587.1
- Published：2016，
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[1]熊昕,隆敏,蔡雷琴,郑宏庭.一种新型的降糖药物——SGLT2抑制剂研究进展[J].重庆医科大学学报,2016,41(11):1172-1176.

Xiong Xin, Long Min, Cai Leiqin, et al. Research progress of a new anti-diabetic agent:SGLT2 inhibitors. [J]. Journal of Chongqing Medical University 41(11):1172-1176(2016)
[1]熊昕,隆敏,蔡雷琴,郑宏庭.一种新型的降糖药物——SGLT2抑制剂研究进展[J].重庆医科大学学报,2016,41(11):1172-1176. DOI： 10.13406/j.cnki.cyxb.001056.

Xiong Xin, Long Min, Cai Leiqin, et al. Research progress of a new anti-diabetic agent:SGLT2 inhibitors. [J]. Journal of Chongqing Medical University 41(11):1172-1176(2016) DOI： 10.13406/j.cnki.cyxb.001056.

摘要

钠-葡萄糖协同转运蛋白2（sodium-glucose transporter 2

SGLT2）是介导肾小管内葡萄糖重吸收的关键蛋白分子

也是近年研究证实的降糖治疗新靶点。针对该靶点所开发研制的SGLT2特异性抑制剂成为目前最具前景的降糖药物。本文就SGLT2抑制剂降糖机制、临床应用、有效性及安全性等作一综述

并对该种药物提出新的思考。

Abstract

Sodium-glucose transporter 2(SGLT2)play an essential role in glucose reabsorption of renal tubules

and the new treatment targeting this protein molecule has become one of the most potential therapeutic strategies for diabetes. Thus

SGLT2 inhibitors are proved to be the new promising anti-diabetes agents developed for the target. Here

this review summarized the mechanism

clinical application

efficacy and safety of SGLT2 inhibitors according to existing studies and a new perspective of the current status of SGLT2 inhibitors was also included.

关键词

糖尿病钠-葡萄糖转运蛋白2降糖药

Keywords

diabetes mellitussodium-glucose transporter 2hypoglycemic agents

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Related Institution

Department of Endocrinology,The First Affiliated Hospital of Chongqing Medical University

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重庆医科大学第一医院内科教研室

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