Effects of parathyroid hormone and alendronate on body composition in postmenopausal osteoporosis patients

Li Yue; Feng Zhengping; Deng Jing; Liao Kun; Li Qifu

doi:10.13406/j.cnki.cyxb.001054

您当前的位置：

首页 >

文章列表页 >

Effects of parathyroid hormone and alendronate on body composition in postmenopausal osteoporosis patients

更新时间：2024-01-17

- Effects of parathyroid hormone and alendronate on body composition in postmenopausal osteoporosis patients
- Journal of Chongqing Medical University Vol. 41, Issue 11, Pages: 1121-1124(2016)
- 作者机构：
  
  重庆医科大学附属第一医院内分泌内科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.001054
  CLC： R580
- Published：2016，
扫描看全文
[1]李月,冯正平,邓静,廖琨,李启富.PTH和ALN对绝经后骨质疏松患者身体成分的影响[J].重庆医科大学学报,2016,41(11):1121-1124.

Li Yue, Feng Zhengping, Deng Jing, et al. Effects of parathyroid hormone and alendronate on body composition in postmenopausal osteoporosis patients. [J]. Journal of Chongqing Medical University 41(11):1121-1124(2016)
[1]李月,冯正平,邓静,廖琨,李启富.PTH和ALN对绝经后骨质疏松患者身体成分的影响[J].重庆医科大学学报,2016,41(11):1121-1124. DOI： 10.13406/j.cnki.cyxb.001054.

Li Yue, Feng Zhengping, Deng Jing, et al. Effects of parathyroid hormone and alendronate on body composition in postmenopausal osteoporosis patients. [J]. Journal of Chongqing Medical University 41(11):1121-1124(2016) DOI： 10.13406/j.cnki.cyxb.001054.

摘要

目的:探讨重组人甲状旁腺素（parathyroid hormone

PTH）和阿仑膦酸钠（alendronate

ALN）对绝经后骨质疏松患者身体成分的影响。方法:绝经后骨质疏松患者64例随机分为2组（PTH组42例

ALN组22例）

分别接受PTH和ALN治疗48周

观察其身体各部分脂肪组织及肌肉组织的变化。结果:PTH组全身脂肪含量增加（P=0.000）

其中皮下脂肪组织的增加主要以上肢、腰臀部为主

内脏脂肪含量明显增加（P=0.000）;ALN组仅全身脂肪及躯体脂肪增加（P=0.000

P=0.003）

其余脂肪组织变化没有统计学差异;2组的全身及躯体肌肉组织较治疗前减少。基线水平时患者血清PTH水平与脂肪组织呈正相关

其中PTH与臀部脂肪的相关性最高（r=0.396

P=0.001）。结论:绝经后骨质疏松患者予以PTH治疗后皮下脂肪和内脏脂肪组织含量增加。

Abstract

Objective:To probe in the effects of recombined human parathyroid hormone(PTH)and alendronate(ALN)on body composition in postmenopausal osteoporosis patients. Methods:Totally 64 patients with postmenopausal osteoporosis were enrolled and were randomly distributed to two groups(42 patients in PTH group and 22 patients in ALN group). PTH and ALN treatments were respectively given to two groups for 48 weeks. During this period

changes of body composition were observed. Results:Total body fat mass was increased(P=0.000)in patients who were treated by the PTH method with a noticeable increase in upper limbs fat mass

android fat mass

gynoid fat mass and visceral fat mass(P=0.000). Among patients who were treated with ALN method

total body fat mass and trunk fat mass were increased(P=0.000

P=0.003)and there was no statistical difference in other fat tissues. However

there was a decline of body lean mass in both two groups. Serum PTH level had a positive relation with body fat mass(r=0.396

P=0.001).Conclusion:The subcutaneous fat tissue and visceral fat tissue of postmenopausal osteoporosis patients are increased after PTH treatment.

关键词

甲状旁腺素阿仑膦酸钠身体成分

Keywords

parathyroid hormonealendronatebody composition

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Blood 25-hydroxyvitamin D concentration,parathyroid hormone concentration,and risk of incident hypertension:a dose response Meta-analysis

An in vivo study of inhibitory effect of erythromycin and alendronate on titanim particle induced osteolysis

Research progress on characteristics of body composition and its related influencing factors in patients with type 2 diabetes mellitus

Related Author

Huang Yanhong

Zhou Liang

Chen Hongru

Yi Dali

Zhang Yanqi

Wu Yazhou

Liu Ling

Yi Dong

Related Institution

Teaching and Research Section of Health Statistics,College of Preventive Medicine,Third Military Medical University

Research Institute of Field Surgery,Third Military Medical University

Department of Orthopedics，the Second People’s Hospital of Yinchuan in Ningxia

Department of Endocrinology，The First Affiliated Hospital of Chongqing Medical University

⁰