Effect of the interaction between Gly1057Asp in IRS2 gene and environment on the risk of type 2 diabetes

Gong Lilin; Li Rong; Ren Wei; Wang Zengchan; Wang Zhihong; Yang Maosheng; Zhang Suhua

doi:10.13406/j.cnki.cyxb.001052

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Effect of the interaction between Gly1057Asp in IRS2 gene and environment on the risk of type 2 diabetes

更新时间：2024-01-17

- Effect of the interaction between Gly1057Asp in IRS2 gene and environment on the risk of type 2 diabetes
- Journal of Chongqing Medical University Vol. 41, Issue 11, Pages: 1150-1153(2016)
- 作者机构：
  
  1. 重庆医科大学附属第一医院内分泌科
  2. 重庆医科大学感染性疾病分子生物学教育部重点实验室
  3. 吉首大学医学院药理教研室与疾病基因研究室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.001052
  CLC： R587.1
- Published：2016，
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[1]龚莉琳,李蓉,任伟,王增产,汪志红,秧茂盛,张素华.IRS2基因Gly1057Asp与环境交互对2型糖尿病易感性的影响[J].重庆医科大学学报,2016,41(11):1150-1153.

Gong Lilin, Li Rong, Ren Wei, et al. Effect of the interaction between Gly1057Asp in IRS2 gene and environment on the risk of type 2 diabetes. [J]. Journal of Chongqing Medical University 41(11):1150-1153(2016)
[1]龚莉琳,李蓉,任伟,王增产,汪志红,秧茂盛,张素华.IRS2基因Gly1057Asp与环境交互对2型糖尿病易感性的影响[J].重庆医科大学学报,2016,41(11):1150-1153. DOI： 10.13406/j.cnki.cyxb.001052.

Gong Lilin, Li Rong, Ren Wei, et al. Effect of the interaction between Gly1057Asp in IRS2 gene and environment on the risk of type 2 diabetes. [J]. Journal of Chongqing Medical University 41(11):1150-1153(2016) DOI： 10.13406/j.cnki.cyxb.001052.

摘要

目的:探究胰岛素受体底物2（insulin receptor substrate 2

IRS2）基因单核苷酸多态性位点Gly1057Asp与环境间的交互作用对2型糖尿病（type 2 diabetes mellitus

T2DM）易感性的影响。方法:对772例无血缘关系的中国重庆汉族人（T2DM 467例

健康对照305例）进行病例-对照研究。应用限制性片段长度多态性聚合酶链反应联合基因测序法检测IRS2基因Gly1057Asp位点基因型

分析其与T2DM的相关性。采用多因子降维法（multifactor dimensionality reduction

MDR）分析Gly1057Asp位点与老龄、肥胖及高甘油三酯血症间的交互作用对T2DM易感性的影响。结果:IRS2基因Gly1057Asp位点与T2DM相关

GG基因型个体T2DM患病风险是AA基因型的1.42倍（OR=1.422

95%CI=1.037

.949

P=0.029）。MDR分析显示Gly1057Asp位点、年龄、腰围和血浆三酰甘油四个因素构成的交互模型具有统计学意义（P=0.001）。在老龄（年龄

60岁）或腹型肥胖者中

Gly1057Asp位点GG或GA基因型个体T2DM患病风险明显增加;在腹型肥胖的高甘油三酯血症者中

除年龄在40

0岁且具AA基因型者外

其余均易患T2DM（OR=3.342

95%CI=1.168

.561

P=0.026）。结论:同时具有IRS2基因Gly1057Asp位点GG基因型、腹型肥胖和高甘油三酯血症的中国重庆汉族人

可能是T2DM的高危易感人群。

Abstract

Objective:To reveal the effect of the interaction between Gly1057 Asp polymorphism of insulin receptor substrate 2(IRS2)and environment on the susceptibility of type 2 diabetes(T2DM). Methods:The case-report research was performed on 467 patients with T2 DM and 305 normal controls who belong to Chinese Han population from Chongqing. Polymerase chain reaction-restriction fragment length polymorphism and gene sequencing technology genotyped the Gly1057 Asp. The interaction between Gly1057 Asp and the environments including age

obesity and hypertriglyceridemia

were analyzed by the multifactor dimensionality reduction software(MDR). Results:The susceptibility of T2 DM in the persons with GG of Gly1057 Asp was 1.42 times higher than those with AA genotype(OR=1.422

95%CI=1.037~1.949

P=0.029). MDR analysis showed that Gly1057 Asp

age

waist and plasma triglyceride level consisted the four-factor interaction model(P=0.001). GG or GA of Gly1057 Asp increased in the risk of T2 DM of the subjects beyond 60 years old or with abdominal obesity. The subjects with abdominal obesity and hypertriglyceridemia were susceptible to T2 DM

excepting those with AA genotype and between 40 to 60 years old(OR=3.342

95%CI=1.168~9.561

P=0.026). Conclusion:The persons with the GG of Gly1057 Asp in IRS2

abdominal obesity and hypertriglyceridemia together

may be much higher susceptible to T2 DM in Chinese Han population from Chongqing.

关键词

2型糖尿病胰岛素受体底物2基因环境交互作用

Keywords

type 2 diabetesinsulin receptor substrate 2geneenvironmentInteraction

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