Experimental study of the fully biodegradable occluder in a swine model of atrial septal defect

Niu Yunhe; Luo Li; Li Yonggang; Ji Xiaojuan; Bai Yonghong; Wang Hong; Pu Xiaofang; Liu Lingjuan; Yi Qijian

doi:10.13406/j.cnki.cyxb.001032

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Experimental study of the fully biodegradable occluder in a swine model of atrial septal defect

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- Experimental study of the fully biodegradable occluder in a swine model of atrial septal defect
- Journal of Chongqing Medical University Vol. 41, Issue 10, Pages: 1045-1050(2016)
- 作者机构：
  
  1. 重庆医科大学附属儿童医院心血管内科
  2. 重庆医科大学附属儿童医院心胸外科
  3. 重庆医科大学附属儿童医院儿童发育重大疾病国家国际科技合作基地儿科学重庆市重点实验室儿童发育疾病研究教育部重点实验室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.001032
  CLC： R725.4
- Published：2016，
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[1]牛云鹤,罗历,李勇刚,计晓娟,白永虹,王洪,蒲晓芳,刘玲娟,易岂建.全生物可降解型封堵器封堵猪房间隔缺损的实验研究[J].重庆医科大学学报,2016,41(10):1045-1050.

Niu Yunhe, Luo Li, Li Yonggang, et al. Experimental study of the fully biodegradable occluder in a swine model of atrial septal defect. [J]. Journal of Chongqing Medical University 41(10):1045-1050(2016)
[1]牛云鹤,罗历,李勇刚,计晓娟,白永虹,王洪,蒲晓芳,刘玲娟,易岂建.全生物可降解型封堵器封堵猪房间隔缺损的实验研究[J].重庆医科大学学报,2016,41(10):1045-1050. DOI： 10.13406/j.cnki.cyxb.001032.

Niu Yunhe, Luo Li, Li Yonggang, et al. Experimental study of the fully biodegradable occluder in a swine model of atrial septal defect. [J]. Journal of Chongqing Medical University 41(10):1045-1050(2016) DOI： 10.13406/j.cnki.cyxb.001032.

摘要

目的:评估全生物可降解型房间隔缺损（atrial septal defect

ASD）封堵器封堵猪ASD的疗效、组织覆盖情况、降解情况及生物相容性等。方法:15只小型猪经外科开胸术后在心脏超声指引下行房间隔穿刺术

并置入全生物可降解ASD封堵器。术后行心脏超声检查观察封堵效果并测量封堵器大小

于1个月、3个月、6个月及9个月各处死3只

大体肉眼观察组织覆盖情况并测量覆盖面积与封堵器双盘面积;苏木素-伊红染色法（hematoxylin-eosin staining

HE）观察周围组织的炎症反应

酶联免疫吸附分析（enzyme-linked immunosorbent assay

ELISA）测定猪血清白介素-6（interleukin-6

IL-6）水平。结果:除了3只建模失败

其余12只均建模成功并进行了ASD封堵;术中及术后未出现感染、封堵器脱落等并发症。超声结果显示封堵器位置良好

无残余分流。大体解剖标本可见置入ASD封堵器术后1月新生组织部分覆盖封堵器装置表面

术后3个月、6个月及9个月均已完全覆盖。与降解前的封堵器扇面直径比较

术后1个月、3个月及6个月均降低（P<0.05）

且随时间延长降低明显

差异有统计学意义（P<0.05）;与降解前的封堵器高度比较

除了术后1个月无明显差异（P>0.05）

术后3个月、6个月均降低（P<0.05）。与降解前封堵器双盘面积比较

术后1个月、3个月、6个月及9个月均降低（P<0.05）

且随时间延长降低明显

差异有统计学意义（P<0.05）。术后1个月、3个月封堵器周围组织炎症反应明显

在术后6个月、9个月消失;术后3个月及6个月血清IL-6浓度较术前升高（P<0.05）

术后9个月降至正常（P>0.05）

差异有统计学意义。结论:全生物可降解型ASD封堵器在猪ASD模型封堵技术成功率高

组织覆盖迅速

生物相容性与降解效果良好

是一种比较理想的可降解封堵器。

Abstract

Objective:To assess the efficacy

tissue coverage

degradation and bio-compatibility for closure of atrial septal defect(ASD)in an swine model. Methods:The model of ASD was built under echocardiography’s guidance after thoracotomy. Fifteen swines were involved and all swines were sacrificed at 1

9 months after surgery. Doppler echocardiography was used to observe efficacy and measure diameter of occluder disc.Gross anatomy was done to assess tissue coverage and degration. Hematoxylin-eosin staining was done to observe inflammatory reaction. ELISA was used to test the level of IL-6. Results:Except 3 swines died of modeling

12 swines with ASD were built successfully and implanted with biodegradable ASD occluders.No infection or shedding of occluder was observed intra-operative and post-operative. Occluders were placed well and no residual shunt was observed by doppler echocardiography.Occluders’ surface was partly covered with neointima by gross anatomy at 1 month after surgery

while totally covered at 3

9 months.Compared with that of pre-operation

diameter of occluder disc decreased at 1

6 months after surgery(P <0.05) and decreased significantly with the extension of time(P<0.05);compared with that of pre-operation

occluders’ height decreased at 3 months

6months after surgery(P<0.05)

however

there was little change at 1 month after surgery(P >0.05). Compared with that pre-operation

double disc area of occluder decreased at 1

9 months after surgery(P<0.05)and decreased significantly with the extension of time(P<0.05). Compared with that pre-operation

serum IL-6 level increased at 3 months and 6 months(P<0.05)

and declined to normal at 9 months after surgery(P>0.05). Conclusion:With satisfactory effectiveness

bio-compatibility and degradation

the fully biodegradable ASD occluder is ideal for swine model of ASD.

关键词

封堵器生物可降解房间隔缺损聚乳酸猪

Keywords

occluderbio-degradableatrial septal defectpolylactic acidswine

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Related Institution

Department of Cardiothoracic Surgery，the First Affiliated Hospital，Chongqing Medical University

Institue for Acupuncture,School of Traditional Chinese Medicine,Chongqing Medical University

Department of General Surgery,PLA Hospital

Mathematics Teaching and Research Room，College of Basic Medicine，Chongqing Medical University

Department of Cardiology，the Children’s Hospital，Chongqing Medical University，Key Laboratory of Child and Development and Disorder Co-founded by Prouincial Government and Ministry Education，Key Laboratory of Pediatrics in Chongqing，Chongqing International Science and Cooperation Center for Child Development and Disorder

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