Association of OCT4 positive expression with clinic-pathological characteristics in non-small cell lung cancer: a Meta-analysis

Hou Lu; Ge Xiaoqing; Zhang Jin; Qiao Menghan; Yang Kunpeng

doi:10.13406/j.cnki.cyxb.001024

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Association of OCT4 positive expression with clinic-pathological characteristics in non-small cell lung cancer: a Meta-analysis

更新时间：2024-01-17

- Association of OCT4 positive expression with clinic-pathological characteristics in non-small cell lung cancer: a Meta-analysis
- Journal of Chongqing Medical University Vol. 42, Issue 11, Pages: 1438-1443(2017)
- 作者机构：
  
  郑州大学第二附属医院胸外科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.001024
  CLC： R734.2
- Published：2017，
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Hou Lu, Ge Xiaoqing, Zhang Jin, et al. Association of OCT4 positive expression with clinic-pathological characteristics in non-small cell lung cancer: a Meta-analysis. [J]. Journal of Chongqing Medical University 42(11):1438-1443(2017)
DOI：

Hou Lu, Ge Xiaoqing, Zhang Jin, et al. Association of OCT4 positive expression with clinic-pathological characteristics in non-small cell lung cancer: a Meta-analysis. [J]. Journal of Chongqing Medical University 42(11):1438-1443(2017) DOI： 10.13406/j.cnki.cyxb.001024.

摘要

目的:旨在使用Meta分析方法系统评价八聚体结合转录因子4（octamer-binding transcription factor 4

OCT4）表达与非小细胞肺癌（non-small cell lung cancer

NSCLC）临床病理特征的关系。方法:电子检索Pub Med、Embase、中国生物医学文献数据库、中国学术期刊全文数据库、维普中文科技核心全文数据库以及万方数据库

检索时间从建库至2016年3月

查找涉及OCT4表达与NSCLC临床病理特征相关的病例对照研究。参照Cochrane协作网推荐的方法进行筛选及提取数据并评价纳入研究的质量

运用Revman 5.2软件及Stata 12.0软件进行Meta分析。结果:共纳入10个研究

905例患者。OCT4阳性组471例

OCT4阴性组434例。Meta分析结果显示

OCT4阳性表达与肺腺癌（OR=1.75

95%CI=1.22

.53

P=0.003）、低分化癌（OR=2.93

95%CI=1.25

.84

P=0.010）、中分化癌（OR=1.81

95%CI=1.12

.94

P=0.020）、T3/T4期肿瘤（OR=1.95

95%CI=1.10

.45

P=0.020）、术后生存期短（鳞癌:MD=-4.49

95%CI=-7.73

1.55

P=0.003;腺癌:MD=-8.52

95%CI=-9.82

7.23

P=0.000）及总体生存率低下（HR=1.99

95%CI=1.52

.60）关系较为密切

差异均具有统计学意义。结论:OCT4阳性表达与肺腺癌、NSCLC恶性特征以及预后不良密切相关

可以为肺癌靶向治疗提供可靠的科学依据。

Abstract

Objective:To evaluate the association of octamer-binding transcription factor 4（OCT4）positive expressions with clinicpathological characteristics of non-small cell lung cancer（NSCLC）by using meta-analysis. Methods:Case-control studies published until March 2016 involving the correlation between OCT4 and clinic-pathological features of NSCLC were electronically searched in Pub Med

Embase

CNKI

VIP and Wanfang database. Two reviewers independently screened the articles

extracted the data and evaluated the quality of the selected articles based on the recommendation of Cochrane collaboration. And Meta-analysis was performed by using Revman 5.2 and Stata 12.0 software. Results:Ten articles containing 796 cases among which there were 471 cases in OCT4 positive group and 434 cases in OCT negative group were included. Meta results showed that positive expressions of OCT4 had close correlations with adenocarcinoma（OR=1.75

95%CI=1.22 to 2.53

P =0.003）

poor differentiation（OR =2.93

95% CI =1.25

.84

P =0.010）

moderate differentiation（OR=1.81

95%CI=1.12 to 2.94

P=0.020）

T3/T4 stage of primary tumor（OR=1.95

95%CI=1.10 to3.45

P=0.020）and short postoperative lifetime（squamous cell carcinoma:MD=-4.49

95%CI=-7.73 to-1.55

P=0.003;adenocarcinoma:MD=-8.52

95%CI=-9.82 to-7.23

P=0.000）

and low overall survival rate（HR=1.99

95%CI=1.52 to 2.60）

all differences were statistically significant. Conclusion:Positive expressions of OCT4 may be associated with adenocarcinoma

malignant features of NSCLC and poor prognosis

which can provide reliable scientific evidence for targeted therapy.

关键词

非小细胞肺癌八聚体结合转录因子4Meta分析

Keywords

non-small cell lung canceroctamer-binding transcription factor 4Meta analysis

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