Efficacy of remote ischemic postconditioning combined with Edaravone for patients with myocardial ischemia-reperfusion after acute myocardial infarction

Shu Chengfu; Yan Xiaohong; Tan Zhiling; Shi Yufang; Yu Chuankun; Fu Wenjun

doi:10.13406/j.cnki.cyxb.001012

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Efficacy of remote ischemic postconditioning combined with Edaravone for patients with myocardial ischemia-reperfusion after acute myocardial infarction

更新时间：2024-01-17

- Efficacy of remote ischemic postconditioning combined with Edaravone for patients with myocardial ischemia-reperfusion after acute myocardial infarction
- Journal of Chongqing Medical University Vol. 41, Issue 9, Pages: 937-940(2016)
- 作者机构：
  
  1. 武汉大学基础医学院生理学系
  2. 三峡大学第二人民医院心内科
  3. 三峡大学第一人民医院心内科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.001012
  CLC： R542.22
- Published：2016，
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[1]舒承福,严晓红,谭知零,史钰芳,余传坤,付文军.远隔器官后适应联合依达拉奉对急性心肌梗死患者心肌缺血再灌注损伤作用的研究[J].重庆医科大学学报,2016,41(09):937-940.

Shu Chengfu, Yan Xiaohong, Tan Zhiling, et al. Efficacy of remote ischemic postconditioning combined with Edaravone for patients with myocardial ischemia-reperfusion after acute myocardial infarction. [J]. Journal of Chongqing Medical University 41(9):937-940(2016)
[1]舒承福,严晓红,谭知零,史钰芳,余传坤,付文军.远隔器官后适应联合依达拉奉对急性心肌梗死患者心肌缺血再灌注损伤作用的研究[J].重庆医科大学学报,2016,41(09):937-940. DOI： 10.13406/j.cnki.cyxb.001012.

Shu Chengfu, Yan Xiaohong, Tan Zhiling, et al. Efficacy of remote ischemic postconditioning combined with Edaravone for patients with myocardial ischemia-reperfusion after acute myocardial infarction. [J]. Journal of Chongqing Medical University 41(9):937-940(2016) DOI： 10.13406/j.cnki.cyxb.001012.

摘要

目的:探讨远隔器官后适应联合应用依达拉奉对急性心肌梗死患者心肌缺血再灌注损伤的作用。方法:选取2013年01月至2014年12月我院收治的急性心肌梗死患者144例

随机分为I/R组（静脉溶栓治疗）、RPOC组（静脉溶栓治疗+远隔器官后适应治疗）、E组（静脉溶栓+依达拉奉注射液静脉点滴）、ER组（静脉溶栓+远隔器官后适应+依达拉奉注射液静脉点滴）

每组36例

分析各组患者肌酸激酶同工酶（creatine kinase isoenzymes

CKm B）及肌钙蛋白（cardiac troponinⅠ

c Tn I）分泌峰值及其动态变化

同时比较各组患者溶栓治疗后超声心动图指标

治疗后进行随访

观察不良事件发生情况。结果:CKm B、c Tn I峰值在I/R组、E组、RPOC组、ER组患者中依次降低

组间差异均具有统计学意义（P<0.05）;与I/R组比较

E组、EROC组、ER组患者左室舒张末内径（left ventricular enddiastolic

LVED）、计算室壁节段运动指数（wall motion score index

WMSI）均明显降低

左室射血分数（left ventricular ejection fractions

LVEF）%明显升高（P<0.05）;ER组患者LVED、WMSI均明显低于E组和RPOC组（P<0.05）

LVEF%明显高于E组和RPOC组（P<0.05）

WMSI明显低于E组（P<0.05）

但与RPOC组比较差异无统计学意义（P>0.05）;4组患者治疗后均随访3个月

随访期间均无失访和死亡病例

E组、EROC组、ER组再梗死、脑卒中、梗死后心绞痛、心力衰竭等不良事件发生率均明显低于I/R组（P<0.05）

但3组间比较

差异无统计学意义（P>0.05）。结论:远隔器官后适应及依达拉奉的应用都能显著减少CKm B和c Tn I的释放

减轻急性心肌梗死后心室重塑

改善室壁运动

从而减轻心肌再灌注的损伤

改善预后。

Abstract

Objective:To investigate the efficacy of remote ischemic postconditioning with Edaravone for patients with myocardial ischemia-reperfusion after acute myocardial infarction. Methods:Totally 144 cases of patients with acute myocardial infarction were selected and randomly divided into four groups

including I/R group(intravenous thrombolysis)

RPOC group(intravenous thrombolysis+remote ischemic postconditioning)

E group(intravenous thrombolysis +Edaravone injection)

ER group(intravenous thrombolysis +remote ischemic postconditioning+Edaravone injection)

each having 36 cases. The peak value and dynamic changes of CKm B and c Tn I were analyzed and the echocardiographic indexes were compared;the adverse clinical events were observed. Results:There were significant differences between the four groups in the peak value of CKm B

c Tn I and LVED

LVEF%

WMSI(P<0.05). During followup period

the occurring rate of adverse clinical events of E

EROC

ER group were significantly lower than that of I/R group(P<0.05).Conclusion:The application of remote ischemic postconditioning and Edaravone can significantly reduce CKm B and

c Tn I release

reduce the ventricular remodeling

and improve the ventricular wall motion

thereby reducing myocardial reperfusion injury.

关键词

冠心病急性心肌梗死远隔器官后适应依达拉奉心肌缺血再灌注损伤

Keywords

coronary artery diseaseacute myocardial infarc tionremote ischemic postconditioningedaravonemyocardial ischemia-reperfusion

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Related Institution

Cardiovascular Department，The First Affiliated Hospital of Chongqing Medical University

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重庆医科大学病案统计科

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重庆医科大学第二临床学院心内科

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