Mechanism of functional dyspepsia accompanied by mild-to-moderate depression

Wu Huamei; Gu Sai

doi:10.13406/j.cnki.cyxb.000990

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Mechanism of functional dyspepsia accompanied by mild-to-moderate depression

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- Mechanism of functional dyspepsia accompanied by mild-to-moderate depression
- Journal of Chongqing Medical University Vol. 41, Issue 6, Pages: 602-604(2016)
- 作者机构：
  
  重庆医科大学附属第一医院消化内科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.000990
  CLC： R57;R749.4
- Published：2016，
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[1]巫华美,古赛.伴抑郁的功能性消化不良机制初探[J].重庆医科大学学报,2016,41(06):602-604.

Wu Huamei, Gu Sai. Mechanism of functional dyspepsia accompanied by mild-to-moderate depression. [J]. Journal of Chongqing Medical University 41(6):602-604(2016)
[1]巫华美,古赛.伴抑郁的功能性消化不良机制初探[J].重庆医科大学学报,2016,41(06):602-604. DOI： 10.13406/j.cnki.cyxb.000990.

Wu Huamei, Gu Sai. Mechanism of functional dyspepsia accompanied by mild-to-moderate depression. [J]. Journal of Chongqing Medical University 41(6):602-604(2016) DOI： 10.13406/j.cnki.cyxb.000990.

摘要

目的:探索伴轻中度抑郁的功能性消化不良（functional dyspepsia

FD）患者血浆和胃黏膜中5-羟色胺（5-hydroxytryptamine

5-HT）与不伴抑郁的FD患者间的差异

为实验室评估FD患者抑郁程度和治疗疗效提供理论依据。方法:门诊FD患者经医院焦虑抑郁量表（hospital anxiety and depression scale

HADS）抑郁评分分为2组

即伴轻中度抑郁的FD试验组30例和不伴抑郁的FD对照组30例

采集2组患者的血液和胃黏膜标本

酶联免疫吸附法（enzyme-linked immunosorbent method

ELISA）法检测血浆及胃黏膜中5-HT的含量。结果:试验组血浆及胃黏膜5-HT含量均较对照组增高

2组差异有统计学意义（P=0.000）;抑郁程度评分与血浆5-HT含量成正相关（r=0.921

P=0.000）

同时也与胃黏膜5-HT含量成正相关（r=0.954

P=0.000）。结论:FD伴轻中度抑郁时存在神经内分泌的异常

5-HT在其发病过程中起重要作用

其可作为FD患者抑郁程度评估和抗抑郁疗效评估的依据之一。

Abstract

Objective:To explore the difference of 5-hydroxytryptamine(5-HT)between functional dyspepsia(FD)patients with or without mild-to-moderate depression and to provide theoretical basis for the treatment and assessment. Methods:Clinic patients with FD were divided into two groups based on hospital anxiety and depression scale(HADS):trial group(30 FD patients with mild-tomoderate depression)and control group of(30 FD patients without depression). The blood specimen and gastric mucosa specimen from the two groups were collected. ELISA was applied to detect 5-HT content in plasma and gastric mucosa. Results:The 5-HT content of plasma and gastric mucosa was higher in trial group than in control group

with statistically significant differences between the two groups(P=0.000). Depression score was related with the 5-HT content of plasma(r=0.921

P=0.000)and gastric mucosa(r=0.954

P=0.000). Conclusion:FD complicated with mild-to-moderate depression will incure abnormal change of neuroendocrine. 5-HT may play an important role in the course of illness and can be used as criterion to assess depression severity and antidepressant efficacy for FD patients.

关键词

功能性消化不良抑郁脑肠肽5-羟色胺

Keywords

Functional dyspepsiadepressionbrain-gut peptide5-hydroxytryptamine

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