Influence of metoclopramide on capsule endoscopy:a Meta-analysis

Guo Rui; Shen Hong; Zhao zhenglan; Dai Jianfeng

doi:10.13406/j.cnki.cyxb.000989

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Influence of metoclopramide on capsule endoscopy:a Meta-analysis

更新时间：2024-01-17

- Influence of metoclopramide on capsule endoscopy:a Meta-analysis
- Journal of Chongqing Medical University Vol. 41, Issue 6, Pages: 620-623(2016)
- 作者机构：
  
  1. 四川省医学科学院·四川省人民医院城东病区消化内科
  2. 四川广播电视大学农林卫生学院
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.000989
  CLC： R574.5
- Published：2016，
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[1]郭睿,沈虹,赵正兰,戴建峰.胃复安对胶囊内镜检查影响的Meta分析[J].重庆医科大学学报,2016,41(06):620-623.

Guo Rui, Shen Hong, Zhao zhenglan, et al. Influence of metoclopramide on capsule endoscopy:a Meta-analysis. [J]. Journal of Chongqing Medical University 41(6):620-623(2016)
[1]郭睿,沈虹,赵正兰,戴建峰.胃复安对胶囊内镜检查影响的Meta分析[J].重庆医科大学学报,2016,41(06):620-623. DOI： 10.13406/j.cnki.cyxb.000989.

Guo Rui, Shen Hong, Zhao zhenglan, et al. Influence of metoclopramide on capsule endoscopy:a Meta-analysis. [J]. Journal of Chongqing Medical University 41(6):620-623(2016) DOI： 10.13406/j.cnki.cyxb.000989.

摘要

目的:评价胃复安在胶囊内镜检查中的作用。方法:计算机检索中国知网（2004年1月至2015年9月）、维普（2004年1月至2015年9月）、万方（2004年1月至2015年9月）、Pub Med（2004年1月至2015年9月）、Cochrane Library（2004年1月至2015年9月）、EMbase（2004年1月至2015年9月）数据库

按照纳入和排除标准选取文献、评价质量并提取资料后用Rev Man5.3软件进行Meta分析。结果:纳入8例随机对照实验

共627例患者。Meta分析显示:在全小肠检查完成率和诊断率方面

胃复安组与对照组相比没有统计学差异（RR=1.11

95%CI=0.99

.23

P=0.070;RR=1.10

95%CI=0.95

.27

P=0.210）;在胃通过时间和小肠通过时间方面

胃复安组要短于对照组

差异有统计学意义（SMD=-0.32

95%CI=-0.48

0.16

P=0.000;SMD=-0.35

95%CI=-0.65

0.06

P=0.020）。结论:现有证据显示

胃复安尚不能作为提高胶囊内镜全小肠检查完成率和诊断率的方法

且因为缩短小肠通过时间

不利于小肠病变的检查。但由于纳入研究的文献存在一定的缺陷

可能影响到结果的准确性

因此上述结论还需要更多的多中心、随机、双盲试验来验证。

Abstract

Objective:To evaluate the effect of metoclopramide on capsule endoscopy(CE)examination. Methods:The literature was searched from CNKI(January 2004 to September 2015)

VIP(January 2004 to September 2015)

WANFANG DATA(January 2004 to September 2015)

Pub Med(January 2004 to September 2015)

Cochrane Library(January 2004 to September 2015)

EMbase(January2004 to September 2015). The data were extracted

the quality of studies was evaluated according to the The Cochrane Handbook

and meta-analyses were performed using Rev Man 5.3 software. Results:Eight randomized controlled trials(RCTS)involving 627 patients were included in this study. The Meta-analyses showed that there was no significant difference between the metoclopramide group and control group in the rate of complete small bowel examination(CER)and the diagnostic yield(RR=1.11

95%CI=0.99 to 1.23

P=0.070;RR=1.10

95%CI=0.95 to 1.27

P=0.210). While

the gastric transit time(GTT)and the small bowel transit time(SBTT)of metoclopramide group were much shorter than that of control group(SMD=-0.32

95%CI=-0.48 to-0.16)

P=0.000;SMD=-0.35

95%CI=-0.65 to-0. 06

P =0. 020). Conclusion :Metoclopramide cannot enhance the complete rate and diagnostic rate of small bowel examination

moreover it has an adverse effect on the small bowel examination because it reduces the small bowel transit time.However

the defect in all 8 involved RCTs may affect the accuracy of the results

so more strictly multi-centered RCTs with high quality in large-scale are needed to confirm this result.

关键词

胃复安胶囊内镜干预Meta分析

Keywords

metoclopramidecapsule endoscopyinterveneMeta-analysis

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