Influence of low intensity ultrasound on the expression of hormone receptor in experimental mammary dysplasia

Long Lijie; Zhu Hui

doi:10.13406/j.cnki.cyxb.000986

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Influence of low intensity ultrasound on the expression of hormone receptor in experimental mammary dysplasia

更新时间：2024-01-17

- Influence of low intensity ultrasound on the expression of hormone receptor in experimental mammary dysplasia
- Journal of Chongqing Medical University Vol. 42, Issue 1, Pages: 98-102(2017)
- 作者机构：
  
  重庆医科大学生物医学工程学院、重庆市超声医学工程重点实验室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.000986
  CLC： R445.1;R655.8
- Published：2017，
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[1]龙李洁,朱辉.低强度超声对实验性乳腺增生组织激素受体表达的影响[J].重庆医科大学学报,2017,42(01):98-102.

Long Lijie, Zhu Hui. Influence of low intensity ultrasound on the expression of hormone receptor in experimental mammary dysplasia. [J]. Journal of Chongqing Medical University 42(1):98-102(2017)
[1]龙李洁,朱辉.低强度超声对实验性乳腺增生组织激素受体表达的影响[J].重庆医科大学学报,2017,42(01):98-102. DOI： 10.13406/j.cnki.cyxb.000986.

Long Lijie, Zhu Hui. Influence of low intensity ultrasound on the expression of hormone receptor in experimental mammary dysplasia. [J]. Journal of Chongqing Medical University 42(1):98-102(2017) DOI： 10.13406/j.cnki.cyxb.000986.

摘要

目的:探讨低强度超声对实验性乳腺增生组织激素受体表达的影响。方法:选用健康雌性新西兰大白兔24只

随机分为A、B、C 3组

每组8只

A组（空白对照组）不予造模和治疗

B组（假治疗组）和C组（治疗组）进行造模;造模后

B组给予假治疗

C组给予低强度超声治疗。观察并测定各组大白兔在建模前、建模后及治疗后15 d 3个时间点的乳头高度;通过HE染色观察各组兔乳腺组织的乳腺小叶数、腺泡数和导管上皮层数;通过免疫组化法检测各组兔乳腺组织内雌激素受体α（estrogen receptorα

ERα）、雌激素受体β（estrogen receptorβ

ERβ）和孕激素受体（progesterone receptor

PR）的表达。结果:（1）造模后B、C两组家兔乳头高度明显增高

与A组相比均有统计学意义（P=0.000、P=0.000）;低强度超声治疗后15d

C组家兔乳头高度与B组相比明显减小（P=0.000）。（2）B组与A组相比

其乳腺小叶数、腺泡数和导管上皮层数均明显增加（P=0.000、P=0.000、P=0.000）;低强度超声治疗后15 d

C组比B组的乳腺小叶数、腺泡数和导管上皮层数均显著减少（P=0.000、P=0.000、P=0.000）。（3）B组比A组ERα和PR的表达均升高（P=0.006

P=0.000）;低强度超声治疗后15 d

C组与B组比较

其ERα和PR的表达均降低（P=0.039

P=0.000）;3组间ERβ表达水平的差异并无统计学意义（F=0.013

P=0.987）。结论:通过调控雌孕激素受体的表达可能是低强度超声治疗乳腺增生的一个重要机制。

Abstract

Objective:To observe the influence of low intensity ultrasound on expression of hormone receptor in experimental mammary dysplasia. Methods:Totally 24 female New Zealand rabbits were divided randomly into 3 groups :A

n =8. Group A(control group)received no treatment;group B(sham treatment group)and group C(treatment group)were modeled;after modeling

group B received sham treatment and group C received low-intensity ultrasound. The height of nipple was observed and measured at each time(before modeling

after modeling

15 d after treatment). Pathological changes were observed by HE staining;the expressions of hormone receptor were detected by immunohistochemistry(ERα

ERβ and PR). Results:(1)After modeling

the height of nipple increased obviously in group B and C(P=0.000

P=0.000);the height of nipple decreased in group C after treatment(P=0.000).(2)Compared with those of group A

the number of breast lobular

alveolar and ductal epithelium layer increased obviously in group B(P=0.000

P=0.000

P=0.000);compared with those of group B

the number of breast lobular

alveolar and ductal epithelium layer decreased obviously in group C after treatment(P=0.000

P=0.000

P=0.000).(3)The expressions of ERα and PR in group B were higher than those in group A(P=0.006

P=0.000);the expression of ERα and PR in group C decreased after treatment(P=0.039

P=0.000). There was no statistical significance in the expression of ERβ between the three groups(F=0.013

P=0.987). Conclusion:Regulating the expression of hormone receptor perhaps an important mechanism in low intensity ultrasonic treatment of mammary dysplasia.

关键词

低强度超声乳腺增生雌激素受体α雌激素受体β孕激素受体

Keywords

Low intensity ultrasoundmammary dysplasiaestrogen receptor αestrogen receptor βprogesterone receptor

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