Association between suicide attempt and gene polymorphisms at hypothalamus-pituitary-adrenal axis among youth

Wang Suya; Ran Liuyi; Zhang Shudong; Jin Jiajia; Gan Yao; Ai Ming; Kuang Li

doi:10.13406/j.cnki.cyxb.000982

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Association between suicide attempt and gene polymorphisms at hypothalamus-pituitary-adrenal axis among youth

更新时间：2024-01-17

- Association between suicide attempt and gene polymorphisms at hypothalamus-pituitary-adrenal axis among youth
- Journal of Chongqing Medical University Vol. 41, Issue 8, Pages: 841-845(2016)
- 作者机构：
  
  1. 重庆医科大学附属第一医院心理卫生中心
  2. 重庆医科大学附属大学城医院心理卫生中心
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.000982
  CLC： B846
- Published：2016，
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[1]王苏亚,冉柳毅,张书懂,靳佳佳,甘瑶,艾明,况利.下丘脑-垂体-肾上腺轴系统基因多态性与青年人自杀未遂的关联研究[J].重庆医科大学学报,2016,41(08):841-845.

Wang Suya, Ran Liuyi, Zhang Shudong, et al. Association between suicide attempt and gene polymorphisms at hypothalamus-pituitary-adrenal axis among youth. [J]. Journal of Chongqing Medical University 41(8):841-845(2016)
[1]王苏亚,冉柳毅,张书懂,靳佳佳,甘瑶,艾明,况利.下丘脑-垂体-肾上腺轴系统基因多态性与青年人自杀未遂的关联研究[J].重庆医科大学学报,2016,41(08):841-845. DOI： 10.13406/j.cnki.cyxb.000982.

Wang Suya, Ran Liuyi, Zhang Shudong, et al. Association between suicide attempt and gene polymorphisms at hypothalamus-pituitary-adrenal axis among youth. [J]. Journal of Chongqing Medical University 41(8):841-845(2016) DOI： 10.13406/j.cnki.cyxb.000982.

摘要

目的:探讨下丘脑-垂体-肾上腺（hypothalamic-pituitary-adrenal axis

HPA）轴系统促肾上腺皮质激素释放激素受体1（corticotropin-releasing hormone receptor 1

CRHR1）、促肾上腺皮质激素释放激素结合蛋白（corticotropin-releasing hormone binding protein

CRHBP）以及FK506结合蛋白（FK506 binding protein 5

FKBP5）基因多态性与青年人自杀未遂行为的关联性。方法:采用i MLDRTM多重SNP分型

检测71例自杀未遂青年人（自杀未遂组

年龄15

4岁）和116例健康对照（对照组）CRHR1基因（rs110402、rs7209436）、FKBP5基因（rs3800373、rs1360780）以及CRHBP基因（rs10474485、rs7728378）6个多态位点

并对基因型、等位基因及单体型频率进行比较。结果:6个位点基因型与等位基因频率在病例组和对照组中分布无统计学差异（P

0.05）。由rs110402、rs7209436位点构成的单体型

rs3800373、rs1360780位点构成的单体型

rs10474485、rs7728378构成的单体型在2组之间分布无统计学差异（P

0.05）。矫正精神疾病史后

在多个遗传模式中

rs7728378显示与自杀未遂有关联。共显性模式:C/T（OR=3.53

95%CI=1.45

.64

P=0.011）、T/T（OR=3.40

95%CI=1.04

1.14

P=0.011）;显性模式:C/T-T/T（OR=3.51

95%CI=1.46

.43

P=0.003）;超显性模式:C/T（OR=2.19

95%CI=1.08

.45

P=0.026）;累加模式:C/C、C/T及T/T（OR=1.95

95%CI=1.12

.41

P=0.016）。结论:CRHBP基因位点rs7728378多态性与青年人的自杀未遂相关

该位点的杂合基因型C/T可能增加自杀未遂的风险。

Abstract

Objective:To investigate the correlation between genetic variants of CRHR1

CFHBP

FKBP5 in hypothalamus-pituitaryadrenal(HPA)axis and suicide attempts(SA)among youth. Methods:DNA was obtained from bloods of 187 subjects

including 71 young man with SA and 116 healthy young people as control. Six single nucleotide polymorphisms(SNPs)(rs110402

rs7209436

rs3800373

rs1360780

rs10474485

rs7728378)were genotyped with the improved multiple ligase detection reaction(i MLDR). Binary logistical regression analyses were performed to evaluate the contribution of individual genetic variants to the prediction of SA and haplotype analysis was done for each gene. Results:Between cases and controls

there was no statistical difference in genotype distribution and allelic frequencies of six genetic locus(P >0.05). No haplotype showed significant association with SA(P >0.05). After adjusting history of mental illness

inheritance model analysis showed significant associations between rs7728378 and SA. Codominant model:C/T(OR=3.53

95%CI=1.45 to 8.64

P=0.011)

T/T(OR=3.40

95%CI=1.04 to 11.14

P=0.011);dominant model:C/T-T/T(OR=3.51

95%CI=1.46 to 8.43

P=0.003);overdominant model:C/T(OR=2.19

95%CI=1.08 to 4.45

P=0.026);log-additive model:C/C

C/T and T/T(OR=1.95

95%CI=1.12 to 3.41

P=0.016). Conclusion:CRHBP gene polymorphism may be associated with suicide attempt among youth

and the heterozygous allele of rs77283785 may increase the risk of suicide attempts.

关键词

青年人自杀未遂单核苷酸多态性下丘脑-垂体-肾上腺轴促肾上腺皮质激素释放激素结合蛋白

Keywords

youthSuicide attemptsingle nucleotide polymor phismsHypothalamic-pituitary-adrenal axiscorticotropin-re leasing hormone binding protein

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Related Institution

Department of Endocrinology,the First Affiliated Hospital,Chongqing Medical University

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