Expressions of uPA,PAI-1,and TGF-β1 in the endometrium of patients with intrauterine adhesion and their correlation

Sun Congcong; Wang Jia; Ming Xue; Gao Yanghong; Zhang Yingfeng; Chen Huaimei

doi:10.13406/j.cnki.cyxb.000972

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Expressions of uPA,PAI-1,and TGF-β1 in the endometrium of patients with intrauterine adhesion and their correlation

更新时间：2024-01-17

- Expressions of uPA,PAI-1,and TGF-β1 in the endometrium of patients with intrauterine adhesion and their correlation
- Journal of Chongqing Medical University Vol. 41, Issue 7, Pages: 690-693(2016)
- 作者机构：
  
  重庆医科大学附属大学城医院妇产科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.000972
  CLC： R711.74
- Published：2016，
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[1]孙聪聪,王佳,明雪,高燕洪,张应凤,陈怀梅.宫腔粘连患者子宫内膜组织中uPA、PAI-1、TGF-β1的表达及其相关性研究[J].重庆医科大学学报,2016,41(07):690-693.

Sun Congcong, Wang Jia, Ming Xue, et al. Expressions of uPA,PAI-1,and TGF-β1 in the endometrium of patients with intrauterine adhesion and their correlation. [J]. Journal of Chongqing Medical University 41(7):690-693(2016)
[1]孙聪聪,王佳,明雪,高燕洪,张应凤,陈怀梅.宫腔粘连患者子宫内膜组织中uPA、PAI-1、TGF-β1的表达及其相关性研究[J].重庆医科大学学报,2016,41(07):690-693. DOI： 10.13406/j.cnki.cyxb.000972.

Sun Congcong, Wang Jia, Ming Xue, et al. Expressions of uPA,PAI-1,and TGF-β1 in the endometrium of patients with intrauterine adhesion and their correlation. [J]. Journal of Chongqing Medical University 41(7):690-693(2016) DOI： 10.13406/j.cnki.cyxb.000972.

摘要

目的:探讨尿激酶型纤溶酶原激活剂（urokinase-type plasminogen activator

u PA）、纤溶酶原激活剂抑制因子-l（plasminogen activator inhibitor type 1

PAI-1）及转化生长因子β1（transforming growth factor-beta 1

TGF-β1）在宫腔粘连（intrauterine adhesion

IUA）患者子宫内膜中的表达及与宫腔粘连发生的关系。方法:选取2013年8月至2014年4月于重庆医科大学附属大学城医院40例行宫腔粘连术的IUA患者的子宫内膜作为实验组（其中轻度粘连17例

中度粘连13例、重度粘连l0例）

以45例非IUA患者的子宫内膜作为对照组

采用蛋白免疫印记法和免疫组化法

比较两组子宫内膜组织中u PA、PAI-l及TGF-β1的表达情况。结果:随着粘连程度的加重

实验组子宫内膜中u PA的表达逐渐减少（P<0.05）;而PAI-l及TGF-β1的表达则明显高于对照组（P<0.05）

且重度粘连组中的表达高于轻-中度粘连组（P<0.05）。结论:宫腔粘连患者子宫内膜组织中u PA、PAI-l及TGF-β1的变化可能会促进IUA的发生、发展

且其改变的幅度与宫腔粘连的程度密切相关。

Abstract

Objective:To investigate and analysis the correlation of the protein expression of urokinase-type plasminogen activator(u PA)

plasminogen activator inhibitor type 1(PAI-1)

and transforming growth factor-beta 1(TGF-β1)in the endometrium of patients with intrauterine adhesion(IUA). Methods:The protein expression of u PA

PAI-1and TGF-β1 were detected by Western blot and immunohistochemical(IH). Results:The expression of u PA was decreased along with the increasing of the adhesion severity(P<0.005).On the contrary

the expressions of PAI-1 and TGF-β1 were significantly higher in experimental group than in control group(P<0.005). Conclusion:The changes of u PA

PAI-1 and TGF-β1 may promote the occurrence and development of IUA

and the changing degree is closely related with the degree of intrauterine adhesion.

关键词

子宫内膜宫腔粘连尿激酶型纤溶酶原激活剂纤溶酶原激活剂抑制因子-l转化生长因子β1

Keywords

endometriumintrauterine adhesionurokinase-type plasminogen activatorplasminogen activator inhibitor type 1transforming growth factor-beta 1

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