Effects of hormone replacement therapy to lipid in postmenopausal women: A systemic review

Liu Yuan; Shen Jing; Wang Yuting; Zhang Liwei

doi:10.13406/j.cnki.cyxb.000944

您当前的位置：

首页 >

文章列表页 >

Effects of hormone replacement therapy to lipid in postmenopausal women: A systemic review

更新时间：2024-01-17

- Effects of hormone replacement therapy to lipid in postmenopausal women: A systemic review
- Journal of Chongqing Medical University Vol. 42, Issue 7, Pages: 898-905(2017)
- 作者机构：
  
  重庆医科大学公共卫生与管理学院医学与社会发展研究健康领域社会风险预测治理协同创新中心
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.000944
  CLC： R711.75
- Published：2017，
扫描看全文
Liu Yuan, Shen Jing, Wang Yuting, et al. Effects of hormone replacement therapy to lipid in postmenopausal women: A systemic review. [J]. Journal of Chongqing Medical University 42(7):898-905(2017)
DOI：

Liu Yuan, Shen Jing, Wang Yuting, et al. Effects of hormone replacement therapy to lipid in postmenopausal women: A systemic review. [J]. Journal of Chongqing Medical University 42(7):898-905(2017) DOI： 10.13406/j.cnki.cyxb.000944.

摘要

目的:系统评价不同途径激素补充治疗（hormone replacement therapy

HRT）对绝经妇女血脂影响

指导临床有效安全应用。方法:检索已发表的关于比较试验组（经皮HRT）和对照组1（口服HRT）、试验组（经皮HRT）与对照组2（空白/安慰剂）对血脂及同型半胱氨酸（homocysteine

HCY）的影响的随机对照试验（randomized controlled trials

RCT）;根据Cochrane协作网推荐的系统评价方法对总胆固醇（total cholesterol

TC）、高密度脂蛋白胆固醇（high density lipoprotein cholesterol

HDL-C）、低密度脂蛋白胆固醇（low density lipoprotein cholesterol

LDL-C）、甘油三酯（triglycerides

TG）、HCY进行系统评价。结果:纳入文献22篇

研究对象共1 507人

试验组为609人

对照组1为589人

对照组2为309人。系统评价结果:试验组与对照组2相比

试验组TC值（MD=0.29

95%CI=0.03

.55

P=0.030）

HCY值（MD=0.71

95%CI=0.10

.32

P=0.020）均比对照组明显降低;单用雌激素亚组中

两组LDL-C值均降低

且差异有统计学意义（MD=0.31

95%CI=0.13

.48

P=0.001）;两组TG值和HDL-C值的变化均无统计学差异（MD=-0.02

95%CI=-0.11

.06

P=0.590）

（MD=-0.02

95%CI=-0.13

.09

P=0.750）。试验组与对照组1相比

TC值、LDL-C值、TG值、和HCY值的变化均无统计学差异

结果分别为:（MD=0.03

95%CI=-0.14

.20

P=0.730）

（MD=-0.04

95%CI=-0.13

.04

P=0.270）

（MD=0.05

95%CI=-0.16

.26

P=0.650）

（MD=0.32

95%CI=-0.47

.11

P=0.420）。HDL-C值的变化无统计学差异（MD=0.01

95%CI=-0.10

.12

P=0.860）

但单用雌激素亚组中

2组HDL-C值均明显降低

且差异有统计学意义（MD=0.19

95%CI=0.10

.28

P=0.000）。结论:经皮HRT与口服HRT相比

对血脂及HCY的影响几乎无差别

但与未接受HRT的女性相比

经皮HRT对血脂及HCY的影响是有益的

可能对心血管疾病有一级预防作用。

Abstract

Objective:To evaluate the effects of hormonal replacement therapy（HRT）on lipid in postmenopausal women by metaanalysis. Methods:Databases of Pub Med

Ovid and Embase were searched from January 1985 to December 2012. Randomized controlled trials（RCTs）assessing the efficacy of different HRT for cardiovascular diseases（CVD）in postmenopausal women were collected. Pooled odds ratio（OR）with the 95% confidence interval（CI）was calculated using random-effect or fixed-effect model when appropriate.Total cholesterol（TC）

high density lipoprotein cholesterol（HDL-C）

low density lipoprotein cholesterol（LDL-C）

triglycerides（TG）

homocysteine（HCY）were used based on Cochrane’s recommend. Results:Twenty-two RCTs involving a total of 1 507 premenopausal or postmenopausal women were included in the meta-analysis.Three group were divided:transdermal HRT group

control 1 group（oral HRT）

control 2 group（blank control group）.Levels of TC and HCY were decreased significantly in transdermal HRT group than in control 2 group（MD=0.29

95%CI=0.03 to 0.55

P=0.030）

（MD=0.71

95%CI=0.10 to 1.32

P=0.020）. Levels of HDLC（MD=-0.02

95%CI=-0.13 to 0.09

P=0.750）and TG（MD=-0.02

95%CI=-0.11 to 0.06

P=0.590）were not significantly changed in transdermal HRT group and control 1 group. Levels of LDL-C were decreased significantly in transdermal HRT estrogen-only subgroup（MD=0.31

95%CI=0.13 to 0.48

P=0.001）. There was no significant change in level of TC

LDL-C

TG and HCY between transdermal HRT group and control 1 group（MD=0.03

95%CI=-0.14 to 0.20

P=0.730）

（MD=-0.04

95%CI=-0.13 to 0.04

P=0.270）

（MD =0.05

95% CI =-0.16 to 0.26

P =0.650）

（MD =0.32

95%CI=-0.47 to 1.11

P=0.420）. Levels of HDL-C（MD=0.01

95%CI=-0.10 to 0.12

P=0.860）were not significantly changed

but in estrogen-only subgroup

levels of HDL-C were decreased obviously

and there were significantly statistic differences between transdermal HRT group and control 1 group（MD=0.19

95%CI=0.10

.28

P=0.000）. Conclusion:There is no difference between transdermal HRT and oral HRT concerning lipid and HCY. Compared with females do not receive HRT

females had transdermal HRT had better lipid and HCY;therefore transdermal HRT may be conducive to preventing CVD.

关键词

系统评价激素补充治疗心血管疾病血脂同型半胱氨酸

Keywords

system reviewhormonal replacement therapycardiovascular diseaseblood lipidhomocysteine

references

Views

120

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

The mechanism of Bu-Yang-Huan-Wu decoction in treating acute cerebral infarction by evaluating the levels of serum procalcitonin and homocysteine

Nutrient deprivation induced autophagy mechanism and the regulation on cardiovascular disease

Clinical value of plasma Cys C,Hcy,sICAM-1 for early detection of diabetic nephropathy

AN OBSERVATION ON OF CHANGE OF ECG FOR PATIENTS WITH PRESENT ABNORMAL ECG IN ESWL

Analysis of relation between body mass index,waist circumference and blood pressure,blood lipid,blood glucose in Chinese pilots

Related Author

Heng Wang

Tingting Li

Chenghui Wang

Fan Gong

Jianli Ni

Jun Wang

Weidong Pan

Wei Hongchang

Related Institution

Department of Traditional Chinese Medicine，Chongming Branch of Xinhua Hospital，Shanghai Jiao Tong University School of Medicine

Department of Encephalopathy，Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

Department of Pathlolgy,Shanghai University of Traditional Chinese Medicine

Department of Diabetes Mellitus,the First Affiliated Hospital of Kunming Medical University

重庆医科大学碎石中心

⁰