Curcumin improves AD transgenic mice’s cognitive function via regulating the expression of α-synuclein and MAP2

Yang Jun; Dai Songyang; Kang Qingmei; Zhang Xiong; Lin Xiao; Li Yu

doi:10.13406/j.cnki.cyxb.000937

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Curcumin improves AD transgenic mice’s cognitive function via regulating the expression of α-synuclein and MAP2

更新时间：2024-01-17

- Curcumin improves AD transgenic mice’s cognitive function via regulating the expression of α-synuclein and MAP2
- Journal of Chongqing Medical University Vol. 41, Issue 8, Pages: 809-813(2016)
- 作者机构：
  
  1. 重庆医科大学基础医学院病理教研室
  2. 重庆医科大学基础医学院神经科学中心
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.000937
  CLC： R285.5
- Published：2016，
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[1]杨军,戴颂阳,康清梅,张雄,林晓,李昱.姜黄素通过调节α-synuclein和MAP2的表达改善AD转基因鼠的认知功能[J].重庆医科大学学报,2016,41(08):809-813.

Yang Jun, Dai Songyang, Kang Qingmei, et al. Curcumin improves AD transgenic mice’s cognitive function via regulating the expression of α-synuclein and MAP2. [J]. Journal of Chongqing Medical University 41(8):809-813(2016)
[1]杨军,戴颂阳,康清梅,张雄,林晓,李昱.姜黄素通过调节α-synuclein和MAP2的表达改善AD转基因鼠的认知功能[J].重庆医科大学学报,2016,41(08):809-813. DOI： 10.13406/j.cnki.cyxb.000937.

Yang Jun, Dai Songyang, Kang Qingmei, et al. Curcumin improves AD transgenic mice’s cognitive function via regulating the expression of α-synuclein and MAP2. [J]. Journal of Chongqing Medical University 41(8):809-813(2016) DOI： 10.13406/j.cnki.cyxb.000937.

摘要

目的:观察姜黄素（curcumin）对APPswe/PS1d E9双转基因小鼠认知功能的影响以及对海马组织中α-突触素（α-synuclein）和微管相关蛋白2（microtubule associated protein-2

MAP2）表达的影响

并探讨其可能的机制。方法:将3月龄APPswe/PS1d E9双转基因小鼠随机分为未处理组、姜黄素低剂量组和姜黄素高剂量组

每组10只

未处理组给予正常饲料

低、高剂量姜黄素组按照160、1 000 mg/kg拌饲喂养

连续喂养6个月

采用Morris水迷宫检测姜黄素对双转基因鼠空间学习记忆能力的影响;采用免疫组化检测姜黄素对双转基因鼠海马中α-synuclein和MAP2表达的影响。结果:Morris水迷宫实验表明姜黄素可以明显改善双转基因鼠学习记忆能力（P<0.05）;免疫组化结果显示与未处理组相比

低、高剂量姜黄素处理组小鼠海马内α-synuclein阳性细胞数均减少（P<0.05）

呈剂量依赖性;但MAP2阳性表达随着姜黄素浓度的升高而增加（P﹤0.05）。结论:姜黄素可能通过抑制α-synuclein表达并增强MAP2的表达

从而改善AD转基因鼠的认知和记忆功能起到神经保护作用。

Abstract

Objective:To observe the effects of curcumin on cognitive function of APPswe/ PS1 d E9 double transgenic mice and the expression of α-synuclein and MAP2 in hippocampus

and to explore the potential mechanisms. Methods:The 3-month-old APPswe/PS1 d E9 double transgenic mice were randomly divided into untreated group(n=10)

curcumin low-dose group(n=10)and curcumin high dose group(n=10). Normal diet

diet mixed with 160 mg/kg curcumin and diet mixed with 1 000 mg/kg curcumin were given

respectively. The Morris water maze test was used to detect the effects of curcumin on spatial learning and memory of AD mice. IHC was carried out to evaluate the expression of α-synuclein and microtubule associated protein-2(MAP2)in hippocampus. Results:Morris water maze test showed that curcumin could improve learning and memory of AD mice. IHC results showed that compared with those of untreated group

the expressions of α-synuclein in the hippocampus were significantly reduced in low and high dose of curcumin group;however

the expressions of MAP2 were significantly increased in curcumin treatment group in a dose-dependent manner(P<0.05). Conclusion:Curcumin could play a role in improving cognition and memory ability of AD transgenic mice via upregulating the expression of MAP2 and down-regulating α-synuclein.

关键词

姜黄素阿尔茨海默病α-synuclein微管相关蛋白2

Keywords

curcuminAlzheimer’s diseaseα-synucleinmicrotubule associated protein-2

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Related Institution

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Teaching and Research Section of Pathology，College of Basic Medicine

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