New targets for prevention and treatment of obesity related NAFLD:short-chain fatty acids and short-chain fatty acid receptors signaling pathways

Liang Yinji; Lin Chenli; Wang Shaona; Zhang Yupei; Han Li; Wang Guanlong; Li Yuanyuan; Deng Yuanjun; He Yifang; He Qinyu; Cai Xiaoshuang; Yang Qinhe

doi:10.13406/j.cnki.cyxb.000936

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New targets for prevention and treatment of obesity related NAFLD:short-chain fatty acids and short-chain fatty acid receptors signaling pathways

更新时间：2024-01-17

- New targets for prevention and treatment of obesity related NAFLD:short-chain fatty acids and short-chain fatty acid receptors signaling pathways
- Journal of Chongqing Medical University Vol. 41, Issue 6, Pages: 628-631(2016)
- 作者机构：
  
  1. 暨南大学医学院护理学系
  2. 暨南大学医学院病理学系
  3. 暨南大学医学院汕头市澄海区人民医院妇产科
  4. 暨南大学医学院中医学系
  5. 暨南大学附属第一医院中医科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.000936
  CLC： R575;R589.2
- Published：2016，
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[1]梁荫基,林琛莅,王少娜,张玉佩,韩莉,王观龙,李媛媛,邓远军,何毅芳,何亲羽,蔡小双,杨钦河.肥胖相关非酒精性脂肪性肝病防治的新靶点:短链脂肪酸及其受体信号通路的保护作用[J].重庆医科大学学报,2016,41(06):628-631.

Liang Yinji, Lin Chenli, Wang Shaona, et al. New targets for prevention and treatment of obesity related NAFLD:short-chain fatty acids and short-chain fatty acid receptors signaling pathways. [J]. Journal of Chongqing Medical University 41(6):628-631(2016)
[1]梁荫基,林琛莅,王少娜,张玉佩,韩莉,王观龙,李媛媛,邓远军,何毅芳,何亲羽,蔡小双,杨钦河.肥胖相关非酒精性脂肪性肝病防治的新靶点:短链脂肪酸及其受体信号通路的保护作用[J].重庆医科大学学报,2016,41(06):628-631. DOI： 10.13406/j.cnki.cyxb.000936.

Liang Yinji, Lin Chenli, Wang Shaona, et al. New targets for prevention and treatment of obesity related NAFLD:short-chain fatty acids and short-chain fatty acid receptors signaling pathways. [J]. Journal of Chongqing Medical University 41(6):628-631(2016) DOI： 10.13406/j.cnki.cyxb.000936.

摘要

近年来

全球肥胖相关非酒精性脂肪性肝病（nonalcoholic fatty liver disease

NAFLD）的发病率和患病率不断上升

但其发病机制尚未完全清楚

临床仍缺乏有效防治手段。目前普遍认为肥胖相关NAFLD是一个多系统疾病

最近研究也证实肠道菌群及其代谢产物在肥胖相关NAFLD发病中起重要作用。作为肠道菌群主要代谢产物短链脂肪酸（short-chain fatty acids

SCFAs）

可能通过多种途径（肠道、脂肪组织、肝脏）介导机体炎症反应

直接或间接影响肥胖相关NAFLD的发生发展。因此

从SCFAs及其受体信号通路的角度

探讨肥胖相关NAFLD治疗的药物靶点

将是防治NAFLD的新途径。

Abstract

In recent years

the incidence and prevalence of nonalcoholic fatty liver disease(NAFLD)has been increasing all over the world and the pathogenesis of NAFLD is unclear. But effective methods of prevention and treatment of NAFLD are insufficient. Now it is widely considered that obesity related NAFLD is a multisystem disease. Recent studies have confirmed that the intestinal flora and their metabolites play an important role in the pathogenesis of obesity related NAFLD. As the main metabolites of intestinal flora

short-chain fatty acids(SCFAs)may mediate the systematic inflammatory response

and directly or indirectly affect the incidence and development of obesity related NAFLD through a variety of ways(intestinal

adipose tissue and liver). Therefore

study on SCFAs and short-chain fatty acid receptors signaling pathways will provide new targets for the prevention and treatment of obesity related NAFLD.

关键词

非酒精性脂肪性肝病肥胖短链脂肪酸短链脂肪酸受体

Keywords

nonalcoholic fatty liver diseaseobesityshort-chain fatty acidsshort-chain fatty acid receptors

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