Clinical effect of laparoscopic ovarian drilling and medications in patients with clomiphene resistant polycystic ovary syndrome: a Meta-analysis

Xu Ting; Yang Jie; Bai Shiyu; Song Ji; Jin Jingjing; Xiao Guohong

doi:10.13406/j.cnki.cyxb.000933

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Clinical effect of laparoscopic ovarian drilling and medications in patients with clomiphene resistant polycystic ovary syndrome: a Meta-analysis

更新时间：2024-01-17

- Clinical effect of laparoscopic ovarian drilling and medications in patients with clomiphene resistant polycystic ovary syndrome: a Meta-analysis
- Journal of Chongqing Medical University Vol. 41, Issue 7, Pages: 708-715(2016)
- 作者机构：
  
  广州医科大学附属第三医院生殖医学中心广东省生殖医学重点实验室广州妇产科研究所广东省产科重大疾病重点实验室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.000933
  CLC： R711.75
- Published：2016，
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[1]许婷,杨洁,白诗雨,宋霁,金晶晶,肖国宏.腹腔镜卵巢打孔术与药物治疗克罗米酚抵抗的多囊卵巢综合征临床疗效的Meta分析[J].重庆医科大学学报,2016,41(07):708-715.

Xu Ting, Yang Jie, Bai Shiyu, et al. Clinical effect of laparoscopic ovarian drilling and medications in patients with clomiphene resistant polycystic ovary syndrome: a Meta-analysis. [J]. Journal of Chongqing Medical University 41(7):708-715(2016)
[1]许婷,杨洁,白诗雨,宋霁,金晶晶,肖国宏.腹腔镜卵巢打孔术与药物治疗克罗米酚抵抗的多囊卵巢综合征临床疗效的Meta分析[J].重庆医科大学学报,2016,41(07):708-715. DOI： 10.13406/j.cnki.cyxb.000933.

Xu Ting, Yang Jie, Bai Shiyu, et al. Clinical effect of laparoscopic ovarian drilling and medications in patients with clomiphene resistant polycystic ovary syndrome: a Meta-analysis. [J]. Journal of Chongqing Medical University 41(7):708-715(2016) DOI： 10.13406/j.cnki.cyxb.000933.

摘要

目的:评估腹腔镜卵巢打孔术（laparoscopic ovarian drilling

LOD）与药物治疗克罗米酚抵抗的多囊卵巢综合征（clomiphene citrate resistant-polycystic ovarian syndrome

CCR-PCOS）临床疗效

为临床治疗提供依据。方法:检索2000年1月起至2015年8月Pubmed、中国生物医学文献数据库、中国学术期刊全文数据库、万方数据库中有关CCR-PCOS通过LOD与药物治疗的随机对照试验的文献。运用Rev Man 5.0软件进行Meta分析

对两者的临床疗效包括多胎妊娠率、活胎率、妊娠率、流产率、排卵率、OHSS发生率、子宫内膜厚度和正常月经周期率进行综合评估。结果:本研究纳入了17篇随机对照研究。Meta分析结果表明:LOD组的多胎妊娠率低于药物组（RR=0.22

95%CI=0.09

.54

P=0.001）

子宫内膜厚度小于药物组（WMD=-1.88

95%CI=-2.84

0.91

P=0.000）;活胎率、妊娠率、流产率、排卵率、OHSS发生率、和正常月经周期率LOD组和药物组间差异无统计学意义。结论:LOD能降低多胎妊娠率

且减少子宫内膜厚度

但在活胎率、妊娠率、流产率、排卵率、OHSS发生率、和正常月经周期率方面与药物组相似。本次结果受纳入研究质量限制

尚需更多高质量、大样本、多中心随机对照试验验证。

Abstract

Objective:To evaluate the effectiveness of the methods of induced ovulation in patients with clomiphene resistant polycystic ovary syndrome by laparoscopic ovarian drilling(LOD)or medications. Methods:Data were obtained from Pubmed

CNKI

Wanfang database. All randomized controlled trials(RCTs)involving the effectiveness of laparoscopic ovarian drilling and medications in patients with clomiphene resistant polycystic ovary syndrome were included in the study. The Rev Man 5.0 software package was used for the Meta-analysis. The clinical curative effect included multiple pregenanacy ratelive birth ratepregnancy ratemiscarriage rateincidence of ovarian hyperstimulation syndromeovulation ratemidcycle endometrial thickness

and regular menstruation. Results:Seventeen randomized controlled trials were included. Meta-analysis showed that the multiple pregnancy rate of LOD groups were lower than that of medication group(RR =0.22

95% CI =0.09 to 0.54

P =0.001). And the midcycle endometrial thickness of LOD groups was lower than that of medication group(WMD=-1.88

95%CI=-2.84 to-0.91

P = 0. 000). Howeverthere was no difference in the live birth ratepregnancy ratemiscarriage rateincidence of ovarian hyperstimulation syndromeovulation rate and regular menstruation between LOD group and medication group. Conclusion:LOD can reduce the multiple pregenanacy rate and midcycle endometrial thicknessbut the live birth ratepregnancy ratemiscarriage rateincidence of ovarian hyperstimulation syndromeovulation rate and regular menstruation between LOD group and medication group are similar.

关键词

腹腔镜下卵巢打孔术克罗米酚抵抗多囊卵巢综合征Meta分析

Keywords

laparoscopic ovarian drillingclomiphene citrate resistantpolycystic ovarian syndromeMeta-analysis

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