Analysis of serum lipids of patients with pulmonary tuberculosis and bacterial pneumonia

Bao Meng; Fu Yurong; Yi Zhengjun

doi:10.13406/j.cnki.cyxb.000917

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Analysis of serum lipids of patients with pulmonary tuberculosis and bacterial pneumonia

更新时间：2024-01-17

- Analysis of serum lipids of patients with pulmonary tuberculosis and bacterial pneumonia
- Journal of Chongqing Medical University Vol. 42, Issue 3, Pages: 338-342(2017)
- 作者机构：
  
  1. 潍坊医学院医学检验学系
  2. 潍坊医学院临床医学院
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.000917
  CLC： R521;R446.1;R563.1
- Published：2017，
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Bao Meng, Fu Yurong, Yi Zhengjun. Analysis of serum lipids of patients with pulmonary tuberculosis and bacterial pneumonia. [J]. Journal of Chongqing Medical University 42(3):338-342(2017)
DOI：

Bao Meng, Fu Yurong, Yi Zhengjun. Analysis of serum lipids of patients with pulmonary tuberculosis and bacterial pneumonia. [J]. Journal of Chongqing Medical University 42(3):338-342(2017) DOI： 10.13406/j.cnki.cyxb.000917.

摘要

目的:研究肺结核、肺结核合并细菌性肺炎患者血清脂类特征及与痰涂片结果的相关性。方法:研究对象来自山东省潍坊市第二人民医院

共3组:入院治疗的肺结核患者460例(单一结核组)

肺结核合并细菌性肺炎患者315例(结核合并肺炎组)

同期健康体检者434例(健康对照组)。抽取研究对象清晨空腹血

离心后检测血清总胆固醇(total cholesterol

TC)、甘油三酯(triglyceride

TG)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol

HDL-C)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol

LDL-C)、脂蛋白a(lipoprotein(a)

Lp(a))、载脂蛋白A1(apoprotein A1

Apo A1)、载脂蛋白B(apoprotein B

Apo B)的含量。TC、TG采用酶法测定;HDL-C、LDL-C采用选择性遮蔽直接法测定;Lp(a)、Apo A1、Apo B采用免疫透射比浊法测定。收集患者即时、夜间、次日清晨9份痰液

做抗酸染色镜检

结果用--、1+、2+、3+、4+表示。结果:(1)与健康对照组相比

单一结核组TC、TG、HDL-C、LDL-C、Apo A1、Apo B降低(Z值分别为-5.941、-3.733、-4.170、-6.213、-4.557、-4.022

P值均小于0.001)

Lp(a)升高(Z=-2.399

P=0.016);(2)与健康对照组相比

结核合并肺炎组TC、TG、HDL-C、LDL-C、Apo A1、Apo B降低(Z值分别为-6.894、-3.676、-5.796、-6.287、-5.799、-4.321

P值均小于0.001)

Lp(a)升高(Z=-2.888

P=0.004);(3)与单一结核组相比

结核合并肺炎组TC、HDL-C、LDL-C、Apo A1降低(Z值分别为-5.624、-4.169、-2.237、-4.328

P值分别为0.000、0.000、0.025、0.000);(4)单一结核组痰涂片结果与Apo A1相关(rs=-0.319

P=0.000)

结核合并肺炎组痰涂片结果与HDL-C、Apo A1相关(rs值分别为-0.175、-0.302

P值分别为0.002、0.000)。结论:(1)血清TC、TG、HDL-C、LDL-C、Lp(a)、Apo A1和Apo B可辅助诊断肺结核;(2)TC、HDL-C、LDL-C、Apo A1可区分肺结核、肺结核合并细菌性肺炎两种疾病;(3)Apo A1有望成为肺结核患者病情严重程度的诊断标准

HDL-C、Apo A1有望成为肺结核合并细菌性肺炎患者病情严重程度的诊断标准。

Abstract

Objective:To study the characteristics of serum lipids of patients with pulmonary tuberculosis and bacterial pneumonia and to explore its correlation with sputum smear results. Methods:Objects were from the Second People’s Hospital in Weifang city

Shandong province. There were there groups:460 pulmonary tuberculosis patients treated in hospital（single-tuberculosis group）

315 pulmonary tuberculosis & bacterial pneumonia patients treated in hospital（tuberculosis & pneumonia group）

and 434 healthy check-ups in the same period（healthy controls）. Objects’ fasting blood was drawn in the morning

then centrifuged and the concentration of serum total cholesterol（TC）

triglyceride（TG）

high density lipoprotein cholesterol（HDL-C）

low density lipoprotein cholesterol（LDL-C）

lipoprotein（a）（Lp（a））

apoprotein A1（Apo A1）

and apoprotein B（Apo B） was tested. TC and TG were tested by enzymic method

HDL-C and LDL-C were tested by selective-covered direct method

Lp（a）

Apo A1 and Apo B were tested by immunoturbidimetic assay. Patient ’s sputum of real time

night and next morning was selected

acid-fast staining and microscopic examination were done. The results were showed by--

4+. Results:（1）Compared with those of healthy controls

HDL-C

LDLC

Apo A1 and Apo B of single-tuberculosis group were reduced（Z=-5.941

-3.733

-4.170

-6.213

-4.557

-4.022

respectively;P=0.000）

while Lp（a）was raised（Z=-2.399

P=0.016）.（2）Compared with those of healthy controls

HDL-C

LDL-C

Apo A1 and Apo B of tuberculosis & pneumonia group were reduced（Z=-6.894

-3.676

-5.796

-6.287

-5.799

-4.321

respectively

P=0.000）

while Lp（a）was raised（Z=-2.888

P=0.004）.（3）Compared with those of single-tuberculosis group

HDL-C

LDL-C and Apo A1 of tuberculosis & pneumonia group were reduced（Z=-5.624

-4.169

-2.237

-4.328

respectively;0.000

0.000

0.025

0.000

respectively）.（4）Sputum smear results of single-tuberculosis group were related with Apo A1（rs=-0.319

P=0.000）

while sputum smear results of tuberculosis & pneumonia group were related with HDL-C and Apo A1（rs=-0.175

-0.302

respectively;P=0.002

0.000

respectively）. Conclusion:（1）TC

HDL-C

LDL-C

Lp（a）

Apo A1

and Apo B are auxiliary test for the diagnosis of pulmonary tuberculosis.（2）TC

HDL-C

LDL-C and Apo A1 can be used to differentiate pulmonary tuberculosis and pulmonary tuberculosis &bacterial pneumonia.（3）Apo A1 is expected to be the disease severity standard for pulmonary tuberculosis

while HDL-C and Apo A1 are expected to be the disease severity standards for pulmonary tuberculosis & bacterial pneumonia.

关键词

结核/肺肺炎血脂痰涂片

Keywords

tuberculosis/pulmonarypneumoniaserum lipidssputum smear

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