Efficacy and safety of lipid emulsion in the early treatment of very low birth weight premature infants:a systematic review

Xiao Feng; Gong Fang; Deng Chun; Tian Mi

doi:10.13406/j.cnki.cyxb.000916

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Efficacy and safety of lipid emulsion in the early treatment of very low birth weight premature infants:a systematic review

更新时间：2024-01-17

- Efficacy and safety of lipid emulsion in the early treatment of very low birth weight premature infants:a systematic review
- Journal of Chongqing Medical University Vol. 41, Issue 9, Pages: 971-975(2016)
- 作者机构：
  
  1. 重庆医科大学附属永川医院儿科
  2. 重庆医科大学附属儿童医院新生儿诊治中心
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.000916
  CLC： R722.6
- Published：2016，
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[1]肖凤,龚放,邓春,田谧.早期脂肪乳治疗早产极低出生体重儿的疗效与安全性的系统评价[J].重庆医科大学学报,2016,41(09):971-975.

Xiao Feng, Gong Fang, Deng Chun, et al. Efficacy and safety of lipid emulsion in the early treatment of very low birth weight premature infants:a systematic review. [J]. Journal of Chongqing Medical University 41(9):971-975(2016)
[1]肖凤,龚放,邓春,田谧.早期脂肪乳治疗早产极低出生体重儿的疗效与安全性的系统评价[J].重庆医科大学学报,2016,41(09):971-975. DOI： 10.13406/j.cnki.cyxb.000916.

Xiao Feng, Gong Fang, Deng Chun, et al. Efficacy and safety of lipid emulsion in the early treatment of very low birth weight premature infants:a systematic review. [J]. Journal of Chongqing Medical University 41(9):971-975(2016) DOI： 10.13406/j.cnki.cyxb.000916.

摘要

目的:系统评价早期脂肪乳治疗早产极低出生体重儿的疗效与安全性。方法:计算机检索Pub Med、Cochrane Central Register of Controlled Trials、MEDLINE、EMBASE、OVID、中国生物医学文献数据库（CBM）、中国期刊全文数据库（CNKI）、中文科技期刊数据库（VIP）、万方数字化期刊全文数据库

检索时间从建库至2015年3月。纳入早期脂肪乳治疗早产极低出生体重儿的所有随机对照试验（randomized controlled trial

RCTs）

并逐个进行质量评价和资料提取。统计学分析采用Rev Man5.2软件进行Meta分析。结果:共纳入13个RCTs

包括852例患者（实验组:440例患者

对照组:412例患者）。Meta分析结果表明

试验组恢复出生体重时间较对照组缩短（MD=-3.09

95%CI=-3.58

2.60

0.000 01）;2组新生儿坏死性小肠结肠炎（necrotizing enterocolitis

NEC）发生率、败血症发生率、黄疸发生率、住院期间死亡率、高甘油三酯血症发生率、低血糖发生率及支气管肺发育不良（bronchopulmonary dysplasia

BPD）发生率无差异[NEC发生率（RR=0.66

95%CI=0.33

.32

P=0.24）;败血症发生率（RR=0.85

95%CI=0.72

.00

P=0.05）;黄疸发生率（RR=1.03

95%CI=0.84

.25

P=0.78）;住院期间死亡率（RR=0.93

95%CI=0.70

.22

P=0.59）;高甘油三酯血症发生率（RR=1.24

95%CI=0.75

.04

P=0.41）;低血糖发生率（RR=1.55

95%CI=0.82

.92

P=0.17）;BPD发生率（RR=0.92

95%CI=0.70

.20

P=0.53）。结论:早期脂肪乳（≤2 d）治疗早产极低出生体重儿是安全有效的

不仅缩短了恢复出生体质量时间

而且并未增加其他不良反应的发生。

Abstract

Objective:To systematically evaluate the efficacy and safety of lipid emulsion in the early treatment of the very low birth weight premature infants. Methods:The Pub Med

Cochrane Central Register of Controlled Trials

MEDLINE

EMBASE

OVID

Chinese biomedical literature database(CBM)

CNKI

VIP

and Wan fang databases journals were searched up to March 2015 to collect the English and Chinese literature about randomized controlled trials(RCTs)of lipid emulsion in the early treatment of the very low birth weight premature infants. The reviewers screened the literature

extracted the data

and assessed the quality according to the method of Jadad’s Scale

and conducted Meta-analysis with Rev Man5.2 software. Results:A total of 13 RCTs were included

including 852patients(experimental group: 440 patients

control group:412 patients). Meta-analysis showed that the recovery of birth weight in the experimental group was shorter than that in the control group(MD =-3.09

95% CI =-3.58 to-2.60

P <0.000 01). There was no significant differences in the incidence of necrotizing enterocolitis(NEC)(RR=0.66

95%CI=0.33 to 1.32

P=0.24)

sepsis(RR=0.85

95%CI=0.72 to 1.00

P=0.05)

jaundice(RR=1.03

95%CI=0.84 to 1.25

P=0.78)

mortality during hospitalization(RR=0.93

95%CI=0.70 to 1.22

P=0.59)

hypertriglyceridemia(RR=1.24

95%CI=0.75 to 2.04

P=0.41)

hypoglycemia(RR=1.55

95%CI=0.82 to 2.92

P=0.17)and bronchopulmonary dysplasia(BPD)(RR=0.92

95%CI=0.70 to 1.20

P=0.53)between the two groups. Conclusion:Early lipid emulsion(≤2 d)is a safe and effective treatment for the very low birth weight premature infants

which can shorten the time of recovery of the birth weight without increasing the incidence of other adverse reactions.

关键词

早产极低出生体重儿早期脂肪乳静脉营养Meta分析

Keywords

very low birth weight premature infantsearly lipid emulsionintravenous nutritionMeta-analysis

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Meng Sun

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Ran Tang

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Related Institution

Department of Neurology，Putuo Hospital，Shanghai University of Traditional Chinese Medicine

Department of Acupuncture, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

Department of Neurology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

Department of Nephrology,the Second Affiliated Hospital,Chongqing Medical University

Department of Hepatobiliary Surgery,the Second Affiliated Hospital,Chongqing Medical University

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