Expression and clinical significance of NEDD9 and FAK in epithelial ovarian cancer

Wang Haixia; Tang Liangdan; Zhou Qi

doi:10.13406/j.cnki.cyxb.000915

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Expression and clinical significance of NEDD9 and FAK in epithelial ovarian cancer

更新时间：2024-01-17

- Expression and clinical significance of NEDD9 and FAK in epithelial ovarian cancer
- Journal of Chongqing Medical University Vol. 41, Issue 3, Pages: 234-238(2016)
- 作者机构：
  
  1. 重庆市肿瘤研究所妇瘤科
  2. 重庆医科大学附属第一医院妇产科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.000915
  CLC： R737.31
- Published：2016，
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[1]王海霞,唐良萏,周琦.NEDD9、FAK在上皮性卵巢癌中的表达及临床意义[J].重庆医科大学学报,2016,41(03):234-238.

Wang Haixia, Tang Liangdan, Zhou Qi. Expression and clinical significance of NEDD9 and FAK in epithelial ovarian cancer. [J]. Journal of Chongqing Medical University 41(3):234-238(2016)
[1]王海霞,唐良萏,周琦.NEDD9、FAK在上皮性卵巢癌中的表达及临床意义[J].重庆医科大学学报,2016,41(03):234-238. DOI： 10.13406/j.cnki.cyxb.000915.

Wang Haixia, Tang Liangdan, Zhou Qi. Expression and clinical significance of NEDD9 and FAK in epithelial ovarian cancer. [J]. Journal of Chongqing Medical University 41(3):234-238(2016) DOI： 10.13406/j.cnki.cyxb.000915.

摘要

目的:探讨神经元细胞表达的发育下调基因9（neural precursor cell-expressed developmentally down-regulated 9

NEDD9）及黏着斑激酶（focal adhesion kinase

FAK）在上皮性卵巢癌中的表达及临床意义。方法:采用免疫组化法检测NEDD9及FAK在52例上皮性卵巢癌、13例卵巢交界性肿瘤、28例卵巢良性肿瘤及17例正常卵巢组织中的表达

并对二者在卵巢癌组织中的表达做相关性分析。结果:NEDD9在上皮性卵巢癌组织中的表达明显高于卵巢交界性肿瘤（P=0.000）、卵巢良性肿瘤（P=0.000）及正常卵巢组织（P=0.000）

差异有统计学意义。FAK在上皮性卵巢癌组织中的表达明显高于卵巢交界性肿瘤（P=0.002）、卵巢良性肿瘤（P=0.000）及正常卵巢组织（P=0.000）

差异有统计学意义。NEDD9的表达在卵巢癌的FIGO分期（P=0.000）、组织分化程度各亚组间有统计学差异（P=0.010）

而在确诊时年龄（P=0.756）、血清CA-125水平（P=0.300）、病理类型（P=0.526）及腹水（P=0.506）各亚组间无统计学差异;FAK的表达在FIGO分期（P=0.008）及腹水（P=0.027）亚组间有统计学差异

而在确诊时年龄（P=0.299）

血清CA-125水平（P=0.116）、组织分化程度（P=0.100）及病理类型（P=1.000）各亚组间无统计学差异。NEDD9和FAK在卵巢癌中的表达成正相关（r=0.535

P<0.05）。结论:NEDD9及FAK在上皮性卵巢癌中高表达

早期联合检测NEDD9和FAK可能对判断上皮性卵巢癌恶性程度有重要的临床意义。

Abstract

Objective:To investigate the expression and significance of neural precursor cell-expressed

developmentally down-regulated 9(NEDD9)and focal adhesion kinase(FAK)in epithelial ovarian cancer(EOC). Methods: Immunohistochemical staining was performed to detect the expression of NEDD9 and FAK in 52 EOC

13 borderline tumors

28 benign tumors and 17 normal ovaries paraffin tissue samples. The correlation between NEDD9 and FAK was analyzed. Results:The expression of NEDD9 in EOC was higher than that in borderline(P =0.000)

benign tumors(P =0.000) and normal ovaries(P =0.000). The expression of FAK in EOC was higher than that in borderline(P=0.002)

benign tumors(P=0.000)and normal ovaries(P=0.000). The expression of NEDD9 was correlated with FIGO stage(P=0.000)and histological differentiation(P=0.010)rather than with the age at diagnosis(P=0.756)

CA125levels(P=0.300)

histologic type(P=0.526)or ascites(P=0.506)

while the expression of FAK was correlated with the FIGO stage(P=0.008)and ascites(P=0.027)rather than with the age at diagnosis(P=0.299)

CA125 levels(P=0.116)

histological differentiation(P=0.100)or histologic type(P=1.000). Spearman correlation coefficient showed that positive correlation was found between NEDD9 and FAK in EOC(r=0.535

P<0.05). Conclusion:NEDD9 and FAK are overexpressed in EOC. Combined screening of NEDD9 and FAK at early stage may have vital clinical significance for evaluation of progress in EOC.

关键词

神经元细胞表达的发育下调基因9黏着斑激酶上皮性卵巢癌

Keywords

neural precursor cell-expressed developmentally down-regulated 9(NEDD9)focal adhesion kinaseepithelial o varian cancer

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