Metabolic profile of stratified degrees of intrahepatic cholestasis of pregnancy based on serum bile acids in mothers and fetuses

Cui Yue; Wang Wenjuan; Tian Gang; Zhang Xiaoqing; Deng Dan; Shao Yong; Ding Min

doi:10.13406/j.cnki.cyxb.000914

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Metabolic profile of stratified degrees of intrahepatic cholestasis of pregnancy based on serum bile acids in mothers and fetuses

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- Metabolic profile of stratified degrees of intrahepatic cholestasis of pregnancy based on serum bile acids in mothers and fetuses
- Journal of Chongqing Medical University Vol. 41, Issue 3, Pages: 228-233(2016)
- 作者机构：
  
  1. 重庆医科大学检验医学院临床检验诊断学教育部重点实验室
  2. 重庆医科大学公共卫生与管理学院卫生统计学教研室
  3. 重庆医科大学附属第一医院妇产科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.000914
  CLC： R714.25
- Published：2016，
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[1]崔悦,王文娟,田刚,张晓清,邓丹,邵勇,丁敏.基于母胎胆汁酸代谢轮廓的妊娠肝内胆汁淤积症分度研究[J].重庆医科大学学报,2016,41(03):228-233.

Cui Yue, Wang Wenjuan, Tian Gang, et al. Metabolic profile of stratified degrees of intrahepatic cholestasis of pregnancy based on serum bile acids in mothers and fetuses. [J]. Journal of Chongqing Medical University 41(3):228-233(2016)
[1]崔悦,王文娟,田刚,张晓清,邓丹,邵勇,丁敏.基于母胎胆汁酸代谢轮廓的妊娠肝内胆汁淤积症分度研究[J].重庆医科大学学报,2016,41(03):228-233. DOI： 10.13406/j.cnki.cyxb.000914.

Cui Yue, Wang Wenjuan, Tian Gang, et al. Metabolic profile of stratified degrees of intrahepatic cholestasis of pregnancy based on serum bile acids in mothers and fetuses. [J]. Journal of Chongqing Medical University 41(3):228-233(2016) DOI： 10.13406/j.cnki.cyxb.000914.

摘要

目的:探讨基于母胎血清胆汁酸代谢轮廓的妊娠肝内胆汁淤积症（intrahepatic cholestasis of pregnancy

ICP）分度。方法:采用高效液相色谱-紫外检测法对61名正常孕妇

轻、重度ICP患者母、脐血的9种结合型胆汁酸成分进行测定

并将受试者分为建模集（n=40）与验证集（n=21）

结合偏最小二乘判别分析对胆汁酸代谢轮廓进行分析、建模与验证。结果:母血胆汁酸代谢模型可区分正常孕妇组

轻度ICP组

与重度ICP组;脐血胆汁酸代谢模型可区分重度ICP组与非重度组。母、脐血分度模型的验证效率分别达90.5%与100.0%。牛磺熊去氧胆酸（P=0.004）

牛磺胆酸（P=0.005）以及甘氨胆酸（P=0.032）在ICP孕妇中明显增高;甘氨石胆酸（P<0.001）和牛磺脱氧胆酸（P=0.001）在ICP胎儿中明显增高。结论:ICP母、脐血各有其特征的胆汁酸代谢轮廓

均可用于对ICP分度。

Abstract

Objective:To investigate the profiles of serum conjugated bile acids in mothers and fetuses for stratifying the degrees of intrahepatic cholestasis of pregnancy(ICP). Methods:High-performance liquid chromatography with ultraviolet detection was used to determinate 9 conjugated bile acids in 61 women and fetuses with stratified degrees of ICP and normal pregnancies. The subjects were divided into modeling(n=40)and validating(n =21) sets. Metabolic profile analysis and validation were performed by partial least squares-discriminant analysis. Results:In the maternal model

the profile of normal pregnancies and stratified degrees of ICP were separated. In the cord model

the profile of non-severe group and severe ICP group were separated. The validated efficiencies of two stratified models were of 90.5% and 100.0%

respectively. The elevation of tauroursodeoxycholic acid(P=0.004)

taurocholic acid(P=0.005)

and glycocholic acid(P =0.032) was greater in ICP mothers

while the elevation of glycolithocholic acid(P <0.001) and taurodeoxycholic acid(P=0.001)was greater in ICP fetuses. Conclusion:Different bile acid profiles exist in mothers and fetuses with ICP available for stratifying degrees of ICP.

关键词

妊娠肝内胆汁淤积症胆汁酸代谢轮廓分度胎盘保护

Keywords

intrahepatic cholestasis of pregnancymetabolic profile of bile acidsstratified degreetransplacental protection

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Related Institution

Department of Laboratory Medicine,Key Laboratory of Clinical Laboratory Diagnostics,Ministry of Education,Chongqing Medical University

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