Efficacy of fibrin glue in total knee arthroplasty:a Meta-analysis

Ding Hao; Rao Feng; Wang Yan; Chen Fuyu; Shi Chenhui; Wang Weishan

doi:10.13406/j.cnki.cyxb.000907

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Efficacy of fibrin glue in total knee arthroplasty:a Meta-analysis

更新时间：2024-01-17

- Efficacy of fibrin glue in total knee arthroplasty:a Meta-analysis
- Journal of Chongqing Medical University Vol. 42, Issue 2, Pages: 158-162(2017)
- 作者机构：
  
  石河子大学医学院第一附属医院骨科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.000907
  CLC： R687.4
- Published：2017，
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Ding Hao, Rao Feng, Wang Yan, et al. Efficacy of fibrin glue in total knee arthroplasty:a Meta-analysis. [J]. Journal of Chongqing Medical University 42(2):158-162(2017)
DOI：

Ding Hao, Rao Feng, Wang Yan, et al. Efficacy of fibrin glue in total knee arthroplasty:a Meta-analysis. [J]. Journal of Chongqing Medical University 42(2):158-162(2017) DOI： 10.13406/j.cnki.cyxb.000907.

摘要

目的:探讨纤维蛋白胶（fibrin glue

FG）在全膝关节置换术（total knee arthroplasty

TKA）中应用的有效性和安全性。方法:通过检索Pub Med、Embase、Cochrane Library、CNKI、CBM、万方等数据库

同时手工检索图书馆馆藏期刊

由2位研究者按照纳入和排除标准独立筛选高质量的随机对照试验（randomized controlled trials

RCTs）文献

采用Rev Man 5.2软件对提取的数据进行统计学分析。结果:共纳入11个RCTs

共973个TKA患者。Meta分析结果显示:与对照组相比

纤维蛋白胶可以减少TKA术后引流（MD=-227.36

95%CI=-359.47

95.25

P=0.001）;血红蛋白丢失量（MD=-0.63

95%CI=-0.79

0.46

P=0.000）;总失血量（MD=-235.59

95%CI=-453.31

17.86

P=0.030）;输血率（OR=0.44

95%CI=0.31

.61

P=0.000）;且不增加术后并发症的发生（OR=0.94

95%CI=0.61

.45

P=0.790）。结论:FG可以有效减少TKA术后引流量

总失血量

血红蛋白丢失量

输血率但不增加术后并发症的发生。

Abstract

Objective:To evaluate the efficacy and safety of fibrin glue in total knee arthroplasty（TKA）. Methods:Studies were searched from Pub Med

Embase

Cochrane Library

CNKI

CBM

Wanfang digital journals and other internet databases. Two independent reviewers searched and assessed high-quality RCTs. The relevant data were analyzed using Rev Man 5.2 software. Results:Eleven studies including a total of 973 patients were included in the analysis. Compared with those in the control group

fibrin glue achieved a decrease in drain volume（MD=-227.36

95%CI=-359.47 to-95.25

P=0.001）

hemoglobin reduction（MD=-0.63

95%CI=-0.79 to-0.46

P=0.000）

transfusion rate（OR=0.44

95%CI=0.31 to 0.61

P=0.000）

total blood loss（MD=-235.59

95%CI=-453.31 to-17.86

P=0.03）

and did not increase the incidence of complications（OR=0.94

95%CI=0.61 to 1.45

P=0.790）. Conclusion:Fibrin glue is effective in TKA without increasing the risk of complications.

关键词

全膝关节置换术纤维蛋白胶Meta分析

Keywords

total knee arthroplastyFibrin glueMeta-analysis

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