Correlation of 25-hydroxy vitaminD3 and insulin resistance with papillary thyroid carcinoma

Jiang Yanyan; Zhang Huijuan

doi:10.13406/j.cnki.cyxb.000899

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Correlation of 25-hydroxy vitaminD3 and insulin resistance with papillary thyroid carcinoma

更新时间：2024-01-17

- Correlation of 25-hydroxy vitaminD3 and insulin resistance with papillary thyroid carcinoma
- Journal of Chongqing Medical University Vol. 41, Issue 12, Pages: 1276-1279(2016)
- 作者机构：
  
  郑州大学第一附属医院内分泌与代谢科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.000899
  CLC： R736.1
- Published：2016，
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[1]蒋燕燕,张会娟.血清25-(OH)D_3、胰岛素抵抗与甲状腺乳头状癌的相关性研究[J].重庆医科大学学报,2016,41(12):1276-1279.

Jiang Yanyan, Zhang Huijuan. Correlation of 25-hydroxy vitaminD3 and insulin resistance with papillary thyroid carcinoma. [J]. Journal of Chongqing Medical University 41(12):1276-1279(2016)
[1]蒋燕燕,张会娟.血清25-(OH)D_3、胰岛素抵抗与甲状腺乳头状癌的相关性研究[J].重庆医科大学学报,2016,41(12):1276-1279. DOI： 10.13406/j.cnki.cyxb.000899.

Jiang Yanyan, Zhang Huijuan. Correlation of 25-hydroxy vitaminD3 and insulin resistance with papillary thyroid carcinoma. [J]. Journal of Chongqing Medical University 41(12):1276-1279(2016) DOI： 10.13406/j.cnki.cyxb.000899.

摘要

目的:探讨血清25-（OH）D

、胰岛素抵抗与甲状腺乳头状癌（papillary thyroid carcinoma

PTC）的相关性。方法:随机选取2014年9月至2015年9月于郑州大学第一附属医院诊断为PTC的患者358例作为观察组

同期健康体检者290例作为正常对照组

检测其血清25-（OH）D

、空腹血糖、空腹胰岛素水平及研究PTC肿瘤组织中B型RAF基因V600E(BRAF

V600E

)表达情况

采用独立样本t检验、Logistic回归分析及Pearson相关性分析进行数据统计分析。结果:1PTC组与正常对照组比较:25-（OH）D

水平较低（P=0.000）

胰岛素抵抗指数（insulin resistance index

IRI）较高（P=0.000）。2PTC组间比较:有淋巴结转移者的血清25-（OH）D

水平及平均年龄低于无淋巴结转移者（P=0.000、P=0.002）

有BRAF

V600E

突变者的血清25-（OH）D

水平低于无BRAF

V600E

突变者（P=0.000）;IRI在PTC有淋巴结转移者或BRAF

V600E

突变者较高（P=0.000）;PTC患者25-（OH）D

水平与IRI未见明显相关。3二元logistic回归分析表明:女性、高胰岛素抵抗是PTC的危险因素（P=0.006、P=0.001）

高25-（OH）D

是PTC保护因素（P=0.000）。结论:高25-（OH）D

可能是PTC的保护因素

改善胰岛素敏感性可能有助于预防PTC的发生发展。

Abstract

Objective:To investigate the correlation of 25-hydroxyvitaminD

and insulin resistance with papillary thyroid carcinoma（PTC）. Methods:Totally 358 patients diagnosed with PTC from September 2014 to September 2015 in the First Affiliated Hospital of Zhengzhou University were randomly selected and taken as observation group and 290 healthy volunteers as control group. The 25-hydoxy vitaminD

fasting blood glucose

fasting insulin of all the members were detected and the expression of BRAFV600 E in PTC was explored. Independent-sample t test

Pearson correlation analysis and logistic regression analysis were used. Results:（1） Significant lower 25-hydoxy vitaminD

concentration（P=0.000）and higher insulin resistance index（IRI）were found in the PTC group（P=0.000）.（2）A significant decrease in 25-hydoxy vitaminD

concentration

age（P=0.000

P=0.002）and increase in IRI（P=0.000）were found in patients with lymph node metastasis or BRAF

V600E

;25-hydoxy vitaminD

concentration had no relation with IRI in patients with PTC.（3）Binary logistic regression analysis showed high insulin resistance and female were risk factors for PTC

while high 25-hydoxy vitaminD

was protective factor. Conclusion:High 25-hydoxy vitaminD

may be a protective factor for PTC. Improving the insulin sensitivity may help prevent the occurrence and development of PTC.

关键词

25-（OH）D3胰岛素抵抗BRAFV600E甲状腺乳头状癌

Keywords

25-hydoxy vitamin D3insulin resistanceBRAFV600Epapillary thyroid carcinoma

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Related Institution

School of Medical Laboratory，Weifang Medical University

Cheeloo College of Medicine，Shandong University

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Graduate School，North China University of Science and Technology

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