Mid-term clinical efficacy of n-HA/PA66 cage in anterior cervical discectomy and fusion

Deng Qianxing; Ou Yunsheng; Jiang Dianming; Liu Bo; Zhu Yong; Zhao Zenghui

doi:10.13406/j.cnki.cyxb.000895

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Mid-term clinical efficacy of n-HA/PA66 cage in anterior cervical discectomy and fusion

更新时间：2024-01-17

- Mid-term clinical efficacy of n-HA/PA66 cage in anterior cervical discectomy and fusion
- Journal of Chongqing Medical University Vol. 41, Issue 5, Pages: 489-494(2016)
- 作者机构：
  
  重庆医科大学附属第一医院骨科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.000895
  CLC： R687.3
- Published：2016，
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[1]邓乾兴,欧云生,蒋电明,刘渤,朱勇,赵增辉.n-HA/PA66椎间融合器在颈椎病前路椎间盘切除减压融合术的中期临床疗效[J].重庆医科大学学报,2016,41(05):489-494.

Deng Qianxing, Ou Yunsheng, Jiang Dianming, et al. Mid-term clinical efficacy of n-HA/PA66 cage in anterior cervical discectomy and fusion. [J]. Journal of Chongqing Medical University 41(5):489-494(2016)
[1]邓乾兴,欧云生,蒋电明,刘渤,朱勇,赵增辉.n-HA/PA66椎间融合器在颈椎病前路椎间盘切除减压融合术的中期临床疗效[J].重庆医科大学学报,2016,41(05):489-494. DOI： 10.13406/j.cnki.cyxb.000895.

Deng Qianxing, Ou Yunsheng, Jiang Dianming, et al. Mid-term clinical efficacy of n-HA/PA66 cage in anterior cervical discectomy and fusion. [J]. Journal of Chongqing Medical University 41(5):489-494(2016) DOI： 10.13406/j.cnki.cyxb.000895.

摘要

目的:探讨纳米羟基磷灰石/聚酰胺66椎间融合器（nano-hydroxyapatite/polyamide66 Cage

n-HA/PA66 Cage）在颈椎病前路单、双节段椎间盘切除减压椎间植骨融合内固定术的中期临床疗效。方法:回顾性分析2009年7月至2012年5月行手术治疗并完整随访的63例患者

均行颈前路减压、n-HA/PA66 Cage椎间植骨融合、钛钉板系统内固定术

颈椎单节段融合45例

双节段融合18例。记录手术时间、术中出血量、术中术后相关并发症。采用视觉模拟疼痛评分（visual analogue scale

VAS）、日本骨科学会评分（Japanese Orthopaedic Association Scores

JOA）、颈椎功能障碍指数（neek disability index

NDI）进行临床疗效评价;影像学评价包括手术节段椎间隙高度、前凸角、植骨融合情况等。结果:63例患者获得30

4个月随访

平均46.9个月。平均手术出血量55.08 ml

手术时间平均为116.98 min。术后11例患者出现短暂吞咽困难

2例患者出现颈部血肿

4例患者发生颈部轴性症状

2例患者并发C5神经根麻痹。单、双节段术后1周、末次随访时VAS评分、JOA评分均较术前改善（P

0.05）;单、双节段术后3个月、末次随访时NDI均较术前改善（P

0.05）。单、双节段术后1周、术后3个月、末次随访时融合节段椎间高度及前凸角均较术前改善（P

0.05）。其中2例单节段出现融合器下沉

1例双节段出现融合器下沉

融合器下沉率4.76%

96.83%患者术后6个月获得骨性融合。所有患者均无脊髓、硬膜囊、喉返神经、喉上神经等损伤

无感染、内固定失败等并发症。结论:n-HA/PA66椎间融合器可有效重建颈椎骨性结构、恢复颈椎曲度、维持颈椎间隙高度

获得良好的中期临床疗效

是一种理想的颈椎椎间植骨融合替代材料。

Abstract

Objective:To explore the mid-term clinical efficacy of nano-hydroxyapatite/polyamide66 cage(n-HA/PA66 cage)in anterior single-level and double-level cervical discectomy

decompression and fusion. Methods:A retrospective analysis was designed and conducted for 63 patients(45 cases were single-level

18 cases were double-level)who had a surgery of anterior cervical discectomy

n-HA/PA66 cage intervertebral fusion

titanium nail plate system internal fixation and had complete follow-up from July 2009 to May 2012. The surgery time

blood loss and complications of the operation were recorded. visual analogue scale scores

Japanese Orthopaedic Association Scores

neek disability index were adopted to assess clinical outcomes

radiology results including the height of intervertebral space

the angle of fused cervical lordosis

the fusion rate

et al. Results:All patients had 30-64 months’ follow-up

an average of 46.9 months. The mean surgery time and blood loss of the operation was 55.08 ml and 116.98 min respectively. Eleven cases occurred temporary dysphagia

2 cases happened neck hematoma

4 cases(6.35%) with cervical axial symptoms

2cases(3.17%)with C5 palsy. The VAS scores and JOA scores in single-level and double-level were improved at one week after the operation and at final follow-up compared with those of pre-operation(P <0.05). The NDI in single-level and double-level was improved at three months after the operation and at final follow-up compared with those of pre- operation(P <0.05). The height of intervertebral space and the angle of fused cervical lordosis in single-level and double-level were increased at one week

three months after the operation and at final follow-up compared with those of pre-operation(P <0.05). Three cases(2 in single-level and 1 in double-level) had subsidence of cage;the subsidence rate of cage was 4.76% at final follow-up. The fusion rate was 96.83% after operation. No other complication(such as tissue injury

infection

screw broken

et al)was observed after the operation. Conclusion:n-HA/PA66 cage can effectively reconstruct the bony structure of cervical

restore the angle of cervical lordosis and can maintain the height of intervertebral space

with favorable clinical curative effects. It can be an ideal pedicle-substitute material for cervical discectomy and fusion.

关键词

纳米羟基磷灰石聚酰胺66椎间融合器颈前路减压融合术内固定

Keywords

Nano-hydroxyapatitePolyamide 66interbody fusion cageanterior cervical decompression and fusioninternal fixation

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