Association between body mass index and the incidence of type 2 diabetes mellitus

Jiang Guangqun; Zhao Libo

doi:10.13406/j.cnki.cyxb.000893

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Association between body mass index and the incidence of type 2 diabetes mellitus

更新时间：2024-01-17

- Association between body mass index and the incidence of type 2 diabetes mellitus
- Journal of Chongqing Medical University Vol. 41, Issue 5, Pages: 521-525(2016)
- 作者机构：
  
  1. 重庆市长寿区疾病预防控制中心
  2. 重庆医科大学附属永川医院神经内科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.000893
  CLC： R587.1
- Published：2016，
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[1]江光群,赵立波.不同体质指数与2型糖尿病关系的队列分析[J].重庆医科大学学报,2016,41(05):521-525.

Jiang Guangqun, Zhao Libo. Association between body mass index and the incidence of type 2 diabetes mellitus. [J]. Journal of Chongqing Medical University 41(5):521-525(2016)
[1]江光群,赵立波.不同体质指数与2型糖尿病关系的队列分析[J].重庆医科大学学报,2016,41(05):521-525. DOI： 10.13406/j.cnki.cyxb.000893.

Jiang Guangqun, Zhao Libo. Association between body mass index and the incidence of type 2 diabetes mellitus. [J]. Journal of Chongqing Medical University 41(5):521-525(2016) DOI： 10.13406/j.cnki.cyxb.000893.

摘要

目的:拟基于体质指数（body mass index

BMI）

研究胰岛素抵抗（insulin resistance

IR）及胰岛素分泌受损（impaired insulin secretion

IIS）和2型糖尿病（type 2 diabetes mellitus

T2DM）发病率的关系。方法:为期5年的队列研究共纳入未患T2DM的参与者2 857名

并根据BMI对其进行分组（BMI

23.0

4.9和≥25.0）。然后

基于胰岛素生成指数和稳态模型中IR值将每组BMI参与者进一步细分为:正常、只有IIS（isolated IIS

i-IIS）、只有IR（isolated IR

i-IR）和同时有IIS和IR（IIS plus IR

IIS+IR）人群。结果:BMI

23.0组中

i-IIS和IIS+IR人群患T2DM的风险明显高于正常人

其风险比（hazard ratios

HRs）及95%置信区间（confidence interval

CI）分别为6.21（3.44

9.75）和8.01（2.85

25.34）;BMI（23.0

4.9）组中

i-IIS[HRs=8.50（3.91

19.67）]、i-IR[HRs=3.16（1.13

8.43）]

和IIS+IR[HRs=20.31（8.74

53.28）]人群患T2DM的风险明显高于正常人;BMI≥25.0组中

i-IIS[HRs=15.58（5.44

44.73）]

、i-IR[HRs=7.78（2.56

22.41）]和IIS+IR[HRs=23.25（8.47

74.68）]

人群患T2DM的风险明显高于正常人。BMI与IIS（相关系数r=-0.45

P=0.032）和IR（r=0.61

P=0.010）的发生率分别呈负相关及正相关。结论:BMI

23.0的人群更可能因IIS患T2DM

而BMI≥23.0的人群则更可能因IR患T2DM。

Abstract

Objectives:To study the effects of impaired insulin secretion(IIS)and insulin resistance(IR)on the incidence of type 2diabetes mellitus(T2DM)in Chinese people with different body mass indexes(BMI). Methods:This five-year cohort study recruited2 857 participants without diabetes at baseline. Participants were stratified according to BMI(<23.0

23.0-24.9

and≥25)

and then participants in each BMI group were divided into four classes:normal;isolated IIS(i-IIS);isolated IR(i-IR);and IIS plus IR based on insulinogenic index and homeostasis model of IR values. Results:The risk of developing T2 DM was higher in i-IIS(HRs=6.21

95%CI=3.44 to 9.75)and IIS plus IR(HRs=8.01

95%CI=2.85 to 25.34)groups than in patients with BMI<23.0in normal group. The risk was higher in i-IIS(HRs=8.50

95%CI=3.91 to 19.67;HRs=15.58

95%CI=5.44 to 44.73)

IR(HRs=3.16

95%CI=1.13 to 8.43;HRs=7.78

95%CI=2.56 to 22.41)and IIS plus IR(HRs=20.31

95%CI=8.74 to 53.28;HRs=23.25

95%CI=8.47 to 74.68)groups than in pa tients with BMI 23.0-24.9 and BMI≥25.0 in normal group. The correlation between BMI and the incidence of IIS was negative

and that with IR was positive. Conclusion:Individuals with normal BMI may develop T2 DM mainly through IIS

whereas individuals with high BMI may develop T2 DM primarily through IR.

关键词

体质指数胰岛素抵抗胰岛素分泌受损2型糖尿病

Keywords

body mass indexinsulin resistanceimpaired insulin secretiontype 2 diabetes mellitus

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