Meta-analysis on the relationship between cyclooxygenase-2 gene polymorphism and gastric cancer in Asian population

Wen Jing; Ren Mengjun; Tan Wei

doi:10.13406/j.cnki.cyxb.000866

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Meta-analysis on the relationship between cyclooxygenase-2 gene polymorphism and gastric cancer in Asian population

更新时间：2024-01-17

- Meta-analysis on the relationship between cyclooxygenase-2 gene polymorphism and gastric cancer in Asian population
- Journal of Chongqing Medical University Vol. 41, Issue 6, Pages: 609-613(2016)
- 作者机构：
  
  重庆市第三人民医院消化内科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.000866
  CLC： R735.2
- Published：2016，
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[1]文静,任孟军,谭伟.亚洲人群环氧化酶-2基因多态性与胃癌关联性的系统性回顾与Meta分析[J].重庆医科大学学报,2016,41(06):609-613.

Wen Jing, Ren Mengjun, Tan Wei. Meta-analysis on the relationship between cyclooxygenase-2 gene polymorphism and gastric cancer in Asian population. [J]. Journal of Chongqing Medical University 41(6):609-613(2016)
[1]文静,任孟军,谭伟.亚洲人群环氧化酶-2基因多态性与胃癌关联性的系统性回顾与Meta分析[J].重庆医科大学学报,2016,41(06):609-613. DOI： 10.13406/j.cnki.cyxb.000866.

Wen Jing, Ren Mengjun, Tan Wei. Meta-analysis on the relationship between cyclooxygenase-2 gene polymorphism and gastric cancer in Asian population. [J]. Journal of Chongqing Medical University 41(6):609-613(2016) DOI： 10.13406/j.cnki.cyxb.000866.

摘要

目的:综合评价亚洲人群环氧化酶-2（cyclooxygenase-2

COX-2）基因多态性与胃癌的关系。方法:以中国生物医学文献光盘数据库（CBMdisc）、CNKI、万方和维普电子数据库为中文文献信息来源

Pub Med、Science Direct、Google学术和Scopus电子数据库为英文文献信息来源

采用主题词和自由词相结合的检索方式

检索2000年1月至2015年2月期间

国内外发表的关于COX-2基因多态性与胃癌研究的相关文献。应用Rev Man 5.0软件对符合条件的研究结果进行Meta分析。结果:共纳入13篇符合纳入标准的文献

包括8篇英文文献和5篇中文文献。数据合并结果显示COX-2-765G>C基因多态性CC基因型、GC基因型与胃癌有明显关联（P<0.05）

而8473T>C、-1195G>A和587G>A基因多态性各基因型与胃癌无显著关系。结论:COX-2-765G>C基因多态性与胃癌发病有显著关联

可能是胃癌发病的危险因子;而8473T>C、-1195G>A和587G>A可能并不是胃癌的易感因素。

Abstract

Objective:To assess the association of cyclooxygenase-2(COX-2)gene polymorphism with gastric cancer by Meta-analysis.Methods:Literatures on the relationship between COX-2 gene polymorphism and gastric cancer from January 2000 to February 2015 were searched in CBMdisc

Wanfang

VIP and CNKI

Pub Med

Science Direct

Google Scholar and Scopus. Thirteen articles were enrolled

including 8 English articles and 5 Chinese articles. Software of Rev Man 5.0 was used. Results:The results show a significant association between COX-2 gene polymorphism-765G>C with gastric cancer

including the allele contrast model

homozygote model and heterozygotes genotypes;however no association was found between COX-2 gene polymorphism 8473 T >C

-1195 G >A

587 G >A and gastric cancer. Conclusion:COX-2 gene polymorphism-765G>C may be the risk of gastric cancer as an independent risk factor

but not the polymorphism 8473T>C

-1195G>A

587G>A.

关键词

胃癌环氧化酶-2基因多态性Meta分析

Keywords

gastric cancerCyclooxygenase-2polymorphismMeta-analysis

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